The substantiation of the choice of a gel former for developing the gel composition with hyaluronic acid and decametoxin




decamethoxine; hyaluronic acid; gelling agent; substantiation


Topicality. Bedsores are an urgent problem of modern medicine both at the outpatient and inpatient stage. For the treatment of infected bedsores it is advisable to use drugs that have a complex effect focused on various parts of the pathological process. For the treatment of chronic wounds and bedsores together with the inhibition of the growth of microorganisms the drug must provide the optimal conditions for the growth of granulation, have a reparative and anti-inflammatory effect.

Aim. To experimentally substantiate the composition of the gel base with hyaluronic acid and decamethoxine.

Materials and methods. To select the structure-forming component in the gel base, the possibility of using “Ultrez 10 NF” carbomer, “Aristoflex AVC” (copolymer of acrylamidomethylpropanesulfonic acid and vinyl pyrrolidone) from Clariant Surfactants company, “Structure XL” (hydropropylated corn starch) as a gelling agent was studied. Organoleptic, physicochemical, structural and mechanical parameters of gel model samples were determined according to the methods of the State Pharmacopoeia of Ukraine. The statistical processing of the results was performed using the Statistica 6.0 program.

Results and discussion. The choice of the optimal gelling agent was performed taking into account the results of the study of organoleptic, physicochemical, structural and mechanical parameters of gel model samples. The experimental studies conducted allowed to choose the optimal gelling agent – “Aristoflex AVC” in the concentration of 1 %. It is easily dispersed with water and does not require the addition of a neutralizer. It has been proven that the base selected has the optimal consumer, structural-mechanical, and physicochemical properties.

Conclusions. Based on the organoleptic, physicochemical, structural-mechanical studies the composition of the gel base with hyaluronic acid and decamethoxine has been experimentally substantiated.

Author Biographies

G. Melnyik, National University of Pharmacy

Doctoral student, of the Department of Drug Technology

T. Yarnykh, National University of Pharmacy

Professor, head of the Department of Drug Technology

M. Buryak, National University of Pharmacy

Candidate of Pharmacy (PhD.), associate professor of the Department of Drug Technology


Klimiashvili, A. D. (2007). Meditsina neotlozhnyih sostoyaniy, 5 (12), 99–103.

Musalatov, H. A. (2002). Meditsinskaia pomosch, 3, 22–28.

Klimiashvili, A. D. (2004). Russkii meditsinskii zhurnal, 12, 40–45.

Liapunov N. A., Bezuhlaia, E. P., Zinchenko, I. A., Liapunov, A. N., Stolper, Yu. M. (2014). Farmatsevticheskaia otrasl, 5, 22–33.

Rukhmakova, O. A., Karpenko, I. A., Yarnykh, T. H. (2018). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 3 (28), 276–280. doi:

Malkin, A. Ya., Isaev, A. I. (2007). Reolohiia: kontseptsii, metody, prilozheniia. Saint Petersburg: Professiya, 557.

Pertsev, I. M. et al. (2010). Dopomizhni rechovyny v tehnolohii likiv: vplyv na tehnolohichni, spozhyvchi, ekonomichni kharakterystyky i terapevtychnu efektyvnist. Kharkiv : Zoloti storinky, 600.

Carbopol® Ultrez 10 Polymer. Technical Data Sheet (TDS-225). (2002). Lubrizol. Cleveland.





Biopharmaceutical research