The choice of excipients to obtain tablets based on the Primula denticulate Smith. Extract by wet granulation
Keywords:tablets; excipients; pharmacotechnological parameters; extract; Primula denticulate Smith
Introduction. Herbal medicines are increasingly being used in the treatment of various diseases. Significant number of resources, high-level availability and the possibility of cultivation have provided high prospects of plant raw materials in the development of new herbal medicines. Primula denticulate Smith. is one of the most interesting medicinal plant raw materials source in modern medicine and pharmacy with the wide spectrum of pharmacotherapeutic action, that is mainly used only in traditional medicine. Thus, nowadays the development of new and effective medicines based on Primula denticulate Smith. in tablet dosage form is the topical task of pharmacy.
The aim of the work. To study the influence of excipients on the pharmacotechnological parameters of tablets with Primula denticulate Smith, are obtained by wet granulation method and to substantiate the choosing of the best excipients by the method of mathematical planning of the experiment.
Materials and Methods. It was used a self-prepared dense extract of Primula denticulate Smith. and excipients, which are complied with the requirements of State Pharmacopoeia of Ukraine in terms of pharmaco-technological quality parameters, for developing tablets. The hyper Greek-Latin square 4x4 was used to study the four qualitative factors.
Results and Discussion. In the course of the experiment, it was determined the dependence of pharmacotechnological parameters (friability, resistance to crushing and disintegration of tablets) on type of excipients. It was selected excipients with the optimal pharmaco-technological parameters for further research the tablets quality.
According to the method of mathematical planning of the experiment, it’s chosen the optimal excipients for obtaining tablets based on dense extract of Primula denticulate Smith. Considering the investigated pharmaco-technological properties (friability, resistance to crushing and disintegration of tablets) the qualitative composition of excipients for obtaining tablets by the method of wet granulation was determined: Avicel PH - 105 and MCC 101, croscarmellose sodium, colloidal anhydrous silicon dioxide, magnesium stearate and Prosolv 90.
Yakovenko, V. K. (2015). Naukovo-teoretychne obgruntuvannia pidkhodiv do upravlinnia yakistiu pry rozrobtsi ta vyrobnytstvi roslynnykh likarskykh zasobiv. Extended abstract of doctor’s thesis. Kharkiv.
Shostak, T. A., Kalyniuk, T. H., Hudz, N. I. (2014). Fitoterapiia. Chasopys, 4, 77–82.
Vyshnevska, L. I. (2008). Visnyk farmatsii, 4, 33–38.
Shostak, H. L., Marchyshyn, S. M., Sira, L. M., Lukaniuk, M. I. (2016). Ukrainskyi biofarmatsevtychnyi zhurnal, 2, 65–70. doi: https://doi.org/10.24959/ubphj.16.23.
Abd El-Aziz, A. B., Abd El-Kalek, H. H. (2011). Antimicrobial proteins and oil seeds from pumpkin (Cucurbita moschata). Nature and Science, 9 (3), 105–119. Available at: http://www.sciencepub.net/nature/ns0903/16_4859ns0903_105_119.pdf.
Marchyshyn, S. M., Sinichenko, A. V. (2016). Investigation of phenolic compounds about ground organs of cultivated species genus Primula L. The Pharma Innovation, 5 (10, Part A), 38. Available at: https://www.thepharmajournal.com/archives/2016/vol5issue10/PartA/5-9-20-899.pdf.
Tokalov, S. V., Kind, B., Wollenweber, E., Gutzeit, H. O. (2004). Biological effects of epicuticular flavonoids from Primula denticulata on human leukemia cells. Journal of agricultural and food chemistry, 52 (2), 239–245. https://doi.org/10.1021/jf0347160.
Singh, S., Farswan, M., Ali, S., Afzal, M., Al-Abbasi, F. A., Kazmi, I., Anwar, F. (2014). Antidiabetic potential of triterpenoid saponin isolated from Primula denticulate. Pharmaceutical biology, 52 (6), 750–755. https://doi.org/10.3109/13880209.2013.869759.
Slobodianiuk, L. V., Sinichenko, A. V., Demydiak, O. L. (2019). Proceeding from Aktualni pytannia farmakolohii ta farmakoterapii: materialy Vseukr. nauk.-prakt. konf. (26-27 veres. 2019 r.). (pp. 67). Ternopil.
Khaleefa, A. (2015). In Vitro Antioxidant, Antibacterial Activity and Phytochemical Studies of Primula Denticulata – An Important Medicinal Plant of Kashmir Himalaya. International Journal of Pharmacological Research, 5 (3), 49–56. doi: https://doi.org/10.7439/ijpr.v5i3.1699.
Budniak, L. I., Vasenda, M. M. (2019). Medychna ta klinichna khimiia, 4, 150–155. doi: 10.11603/mcch.2410-681X.2019.v.i4.10853.
Budniak, L, Vasenda, M, Marchyshyn, S, Kurylo, K (2020). Determination of the optimum extraction regime of reducing compounds and flavonoids of Primula denticulata Smith leaves by a dispersion analysis. Pharmacia, 67 (4), 373–378. https://doi.org/10.3897/pharmacia.67.e54170.
Pertsev, I. M., Dmytriievskyi, D. I., Hudzenko, O. P. et al. (2010). Dopomizhni rechovyny v tekhnolohii likiv: vplyv na tekhnolohichni, spozhyvchi, ekonomichni kharakterystyky i terapevtychnu efektyvnist. Kharkiv: Zoloti storinky, 600.
DP “Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv”. (2014). Derzhavna Farmakopeia Ukrainy. (Vols. 1-3; Vol. 3). (2nd ed.). Kharkiv, 724.
Hroshovyi, T. A., Martsyniuk, V. P., Kucherenko, L. I. et al. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovyh doslidzhen v pharmatsii. Ternopil: Ukrmedknyha, 724.
Hroshovyi, T. A., Demchuk, M. B, Belei, N. M., Naida, Yu. V., Pavliuk, B. V. (2020). Farmatsevtychnyi Chasopys, 2, 101–110. doi: https://doi.org/10.11603/2312-0967.2020.2.11204.
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