Circadian characteristics of the glutargin influence on protein and purine metabolism under the conditions of chronodeterminated acetaminophen hepatitis in rats
DOI:
https://doi.org/10.24959/ubphj.16.58Keywords:
hepatic, protein metabolism, glutarginAbstract
The aim of the work was to determine the circadian characteristics of the glutargin influence on protein and purine metabolism under the conditions of chronodeterminated acetaminophen hepatitis in rats. Typical phatology was simulating by acetaminophen administration (dose of 1000mg/kg on the rat) in such periods and hours of the day and night as morning (9.00), afternoon (15.00), evening (21.00), and night (3.00). The glutargin was administration in medical-preventive regime, that is an hour before the acetaminophen administration and two hours after in dose of 135 mg/kg on the rat. As the results of this investigations was determined that glutargin administration against the background of the chronodeterminated acetaminophen hepatitis hadn’t been characterized by changes of total protein and albumin contents, while the increasing level of carbamide was depending on circadian group of medicament (on 10-33%) and decreasing level of uric acid was only in medicament of 9.00 am group (on 24%).
Obtained results should be taken into consideration in developing of glutargin chronoportrait.
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