The decisive role of the hepatic lipase in the reverse cholesterol transport
DOI:
https://doi.org/10.24959/ubphj.16.17Keywords:
hepatic lipase, atherosclerosis, high-density lipoprotein, very low density lipoproteinAbstract
The review deals with modern data on the hepatic lipase (HL) role in the atherosclerosis development. HL enzyme facilitates the TG output from the pool of the very low density lipoproteins (VLDL), and this function is controlled by the high-density lipoprotein (HDL) particles composition and structure. The composition of HDL regulates the "liberation" of the HL from the liver, and the structure of HDL controls the HL transportation and activation of it in the bloodstream. Although the lipase activity is typically hard to detect in human plasma, heparin infusion increases the mass of HL and stimulates their activity in the circulation. In humans, the HL can be found primarily in association with the hepatocytes and endothelial cells of the liver cell surface. Human HL can be released from the HSPG cell surface via either heparin or HDL. Some results suggest that heparin interacts directly with lipases and / or competes for binding sites on the surface of HSPG cells. Increased levels of apolipoprotein B-containing lipoproteins (Apo- containing lipoproteins), LDL, and chylomicrons are connected with the development of atherosclerosis. Deposition of lipids in monocytes and macrophages leads to the further development of atherosclerosis. In general, these results indicate that dyslipidemia caused by deficiency HL in combination with a diet high in cholesterol causes inflammation of the liver steatosis.
References
Davignon J., Cohn J.S. Triglycerides-Р. a risk factor for coronary heart disease/ Davignon J., Cohn J.S.// Atherosclerosis.-1996.-№124.-Р.57–64.
Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration Triglyceride-mediated pathways and coronary disease-Р. collaborative analysis of 101 studies./ Sarwar N., Sandhu M.S., Ricketts S.L. //.Lancet.- 2010.-№375.-Р.1634–1639. Goldberg I.J. Lipoprotein lipase and lipolysis-Р. central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996-Р.37-Р.693–707. [PubMed]
Zambon A. Hepatic lipase-Р. a marker for cardiovascular disease risk and response to therapy. / Zambon A., Deeb S.S., Pauletto P., Crepaldi G., Brunzell J.D. // Curr Opin Lipidol.- 2003.-№14-Р. 179–189.
Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL), and hepatic lipase (LIPC) genes and coronary artery disease (CAD)-Р. variation in LIPC gene associates with clinical outcomes in patients with established CAD/ Baroni M.G., Berni A., Romeo S., Arca M., Tesorio T., Sorropago G., Di Mario U., Galton D.J.// BMC Med Genet.- 2003.-№4.-Р.8–15.
Connelly P.W. Hepatic lipase deficiency/ Connelly P.W., Hegele R.A.// Crit Rev Clin Lab Sci. -1998.-№35.-Р.547–572.
McCaskie P.A. The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease/ McCaskie P.A., Cadby G., Hung J., McQuillan B.M., Chapman C.M., Carter K.W., Thompson P.L., Palmer L.J., Beilby J.P.// Clin Genet. -№2006.-№70.-Р.114–121.
Hodoglugil U. Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population/ Hodoglugil U., Williamson D.W., Mahley R.W.// J Lipid Res. -2010.-№51-Р.422–430.
Teslovich T.M. Biological, clinical and population relevance of 95 loci for blood lipids/ Teslovich T.M., Musunuru K., Smith A.V., Edmondson A.C., Stylianou I.M., Koseki M.// Nature. 2010-№466-Р. 707–713.
Feitosa M.F. LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion / Feitosa M.F., Myers R.H., Pankow J.S., Province M.A., Borecki I.B.// Atherosclerosis. -2009.-№.204-Р.171–177
Jansen H. Binding of liver lipase to parenchymal and non-parenchymal rat liver cells./ Jansen H., van Berkel T.J., Hülsmann W.C.// Biochem Biophys Res Commun.-1978-№.85-Р.148–152
Kuusi T. Localization of the heparin-releasable lipase in situ in the rat liver/ Kuusi T., Nikklä E.A., Virtanen I., Kinnunen P.K.// Biochem J.- 1979-№.181-Р.245–246
Hahn P.F. Abolishment of alimentary lipemia following injection of heparin //Science. - 1943-№98-Р.19–20
Olivecrona T. New aspects on heparin and lipoprotein metabolism/ Olivecrona T., Bengtsson-Olivecrona G., Ostergaard P., Liu G., Chevreuil O., Hultin M.// Haemostasis -1993-№23(Suppl 1)-Р.150–160.
Kuusi T. Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia/ Kuusi T., Ehnholm C., Viikari J., Härkönen R., Vartiainen E., Puska P., Taskinen M.R.// J Lipid Res. - 1989-№.30-Р.1117–1126.
Patsch J. Influence of lipolysis on chylomicron clearance and HDL cholesterol levels// Eur Heart J. - 1998-№19(Suppl H)-Р.H2–H6.
Santamarina-Fojo S. The role of hepatic lipase in lipoprotein metabolism and atherosclerosis./ Santamarina-Fojo S., Haudenschild C., Amar M.// Curr Opin Lipidol. -1998-№9-Р.211–219
Jansen H. Hepatic lipase-Р. a pro- or anti-atherogenic protein? / Jansen H., Verhoeven A.J., Sijbrands E.J. //J Lipid Res.-2002-№43-Р.1352–1362.
Ramsamy T.A. Apolipoprotein A-I regulates lipid hydrolysis by hepatic lipase./ Ramsamy T.A., Neville T.A., Chauhan B.M., Aggarwal D., Sparks D.L.// J Biol Chem. -2000-№275-Р.33480–33486.
Ramsamy T.A. HDL regulates the displacement of hepatic lipase from cell surface proteoglycans and the hydrolysis of VLDL triacylglycerol./ Ramsamy T.A., Boucher J., Brown R.J., Yao Z., Sparks D.L.// J Lipid Res.-2003-№44-Р.733–741.
Rouhani N. HDL composition regulates displacement of cell surface-bound hepatic lipase./ Rouhani N., Young E., Chatterjee C., Sparks D.L.// Lipids.- 2008-Р.43-Р.793–804.
Young E.K. HDL-ApoE content regulates the displacement of hepatic lipase from cell surface proteoglycans./ Young E.K., Chatterjee C., Sparks D.L.// Am J Pathol.- 2009-№175-Р.448–457.
Sanan D.A. Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver./ Sanan D.A., Fan J., Bensadoun A., Taylor J.M.// J Lipid Res. -1997-№38-Р.1002–1013.
Hill J.S. Subdomain chimeras of hepatic lipase and lipoprotein lipase-Р. Localization of heparin and cofactor binding. / Hill J.S., Yang D., Nikazy J., Curtiss L.K., Sparrow J.T., Wong H .//J Biol Chem. -1998-№273-Р.30979–30984.
Yu W. Mapping the heparin-binding domain of human hepatic lipase./ Yu W., Hill J.S.// Biochem Biophys Res Commun. -2006-№343-Р.659–665.
Schoonderwoerd K. Rat liver contains a limited number of binding sites for hepatic lipase. / Schoonderwoerd K., Verhoeven A.J.M., Jansen H. //Biochem J.- 1994-№302-Р.717–722.
Brown R.J. The amino acid sequences of the carboxyl termini of human and mouse hepatic lipase influence cell surface association./ Brown R.J., Schultz J.R., Ko K.W., Hill J.S., Ramsamy T.A., White A.L., Sparks D.L., Yao Z.// J Lipid Res.- 2003-№44-Р.1306–1314.
Kolset S.O. Cell surface heparan sulfate proteoglycans and lipoprotein metabolism. / Kolset S.O., Salmivirta M.//Cell Mol Life Sci. -1999-№56-Р.857–870.
Tagashira H. Involvement of Ca2+/calmodulin-dependent protein kinase II in heparin-stimulated release of hepatic lipase from rat hepatocytes./ Tagashira H., Nakahigashi S., Kerakawati R., Motoyashiki T., Morita T.// Biol Pharm Bull.- 2005-№28-Р.409–412.
Mowri H.O. Apolipoprotein A-II influences the substrate properties of human HDL2 and HDL3 for hepatic lipase./ Mowri H.O., Patsch, Gotto A.M., Jr, Patsch W.// Arterioscler Thromb Vasc Biol. -1996-№16-Р.755–762.
Boucher J. Apolipoprotein A-II regulates HDL stability and affects hepatic lipase association / Boucher J., Ramsamy T.A., Braschi S., Sahoo D., Neville T.A., Sparks D.L.// J Lipid Res. -2004-№45-Р.849–858.
Boucher J.G. Lipoprotein electrostatic properties regulate hepatic lipase association./ Boucher J.G., Nguyen T., Sparks D.L.// Biochem Cell Biol. -2007-№85-Р.696–708.
Blum C.B. Dynamics of apolipoprotein E metabolism in humans./ Blum C.B.// J Lipid Res. -1982-№23-Р.1308–1316.
Murdoch S.J. Influence of lipoprotein lipase and hepatic lipase on the transformation of VLDL and HDL during lipolysis of VLDL./ Murdoch S.J., Breckenridge W.C.// Atherosclerosis. -1995-№118-Р.193–212.
Murdoch S.J. Effect of lipid transfer proteins on lipoprotein lipase induced transformation of VLDL and HDL./ Murdoch S.J., Breckenridge W.C. //Biochim Biophys Acta. -1996-№ 1303-Р.222–232.
Mowri H.O. Different reactivities of high density lipoprotein2 subfractions with hepatic lipase./ Mowri H.O., Patsch W., Smith L.C., Gotto A.M., JR, Patsch// J Lipid Res. 1992-№33-Р.1269–1279.
Hime N.J. Apolipoprotein E enhances hepatic lipase-mediated hydrolysis of reconstituted high-density lipoprotein phospholipid and triacylglycerol in an isoform-dependent manner. / Hime N.J., Drew K.J., Hahn C., Barter P.J., Rye K.A. //Biochemistry.- 2004-Р.43-№12306–12314.
Deeb S.S. Hepatic lipase and dyslipidemia-Р. interactions among genetic variants, obesity, gender, diet./ Deeb S.S., Zambon A., Carr M.C., Ayyobi A.F., Brunzell J.D.// J Lipid Res. -2003-№44-Р.1279–1286.
Weisgraber K.H. Apoprotein (E–A-II) complex of human plasma lipoproteins-Р. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction./ Weisgraber K.H., Mahley R.W.// J Biol Chem. -1978-№ 253-Р.6281–6288.
Jain M.K. The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation-Р. hopping versus scooting. / Jain M.K., Berg O.G.//Biochim Biophys Acta. -1989-№ 1002-Р.127–156.
Couillard C. Gender difference in postprandial lipemia-Р. importance of visceral adipose tissue accumulation./ Couillard C., Bergeron N., Prud'homme D., Bergeron J., Tremblay A., Bouchard C., Mauriège P., Després J.P. //Arterioscler Thromb Vasc Biol. -1999-№19-Р.2448–2455.
Patsch Karlin J.B. Inverse relationship between blood levels of high density lipoprotein subfraction 2 and magnitude of postprandial lipemia. / Patsch, Karlin J.B., Scott L.W., Smith L.C., Gotto A.M., Jr //Proc Natl Acad Sci USA.-1983-№80-Р.1449–1453.
Chatterjee C. Hepatic high-density lipoprotein секреция regulates the mobilization of cell-surface hepatic lipase./ Chatterjee C., Young E.K., Pussegoda K.A., Twomey E.E., Pandey N.R., Sparks D.L.// Biochemistry.-2009-№ 48-Р.5994–6001.
Pandey N.R. Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein / Pandey N.R., Renwick J., Misquith A., Sokoll K., Sparks D.L. //A-I секреция.Biochemistry. -2008-№47-Р.1579–1587.
Pandey N.R. An induction in hepatic HDL секреция associated with reduced ATPase expression./ Pandey N.R., Renwick J., Rabaa S., Misquith A., Kouri L., Twomey E., Sparks D.L.// Am J Pathol. -2009-№ 175-Р.1777–1787
Ben-Zeev O. Maturation of hepatic lipase-Р. Formation of functional enzyme in the endoplasmic reticulum is the rate-limiting step in its секреция. / Ben-Zeev O., Doolittle M.H. //J Biol Chem. -2004- №279-Р.6171–6181.
Doolittle M.H. Lipase maturation factor 1-Р. structure and role in lipase folding and assembly./ Doolittle M.H., Ehrhardt N., Peterfy M.// Curr Opin Lipidol.- 2010-№ 21-Р.198–203.
Castelli W.P. Incidence of coronary heart disease and lipoprotein cholesterol levels-Р./ Castelli W.P., Garrison R.J., Wilson P.W., Abbott R.D., Kalousdian S., Kannel W.B. // The Framingham Study. JAMA. -1986-Р.256-Р.2835–2838.
Staels B. Mechanism of action of fibrates on lipid and lipoprotein metabolism. / Staels B., Dallongeville J., Auwerx J., Schoonjans K., Leitersdorf E., Fruchart J.C. //Circulation. -1998-№ 98-Р.2088–2093.
Kamanna V.S. Nicotinic acid (niacin) receptor agonists-Р. will they be useful therapeutic agents?/ Kashyap M.L. Am J Cardiol.// 2007-№ 100-Р.S53–S61.
Stahnke G. Human hepatic triglyceride lipase-Р. cDNA cloning, amino acid sequence and expression in a cultured cell line. / Stahnke G, Sprengel R, Augustin J, Will H. //Differentiation. -1987-№ 35-Р.45–52.
Datta S. Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase./ Datta S, Luo CC, Li WH, VanTuinen P, Ledbetter DH, Brown MA, Chen SH, Liu SW, Chan L. // J Biol Chem. 1988-№ 263-Р.1107–1110.
Martin GA. Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase. / Martin GA, Busch SJ, Meredith GD, Cardin AD, Blankenship DT, Mao SJT, Rechtin AE, Woods CW, Racke MM, Schafer MP, Fitzgerald MC, Burke DM, Flanagan MA, Jackson RL.//J Biol Chem.- 1988-№263-Р.10907–10914.
Hide WA. Structure and evolution of the lipase superfamily./ Hide WA, Chan L, Li WH.// J Lipid Res. -1992-№33-Р.167–178.
Jaye M. A novel endothelial-derived lipase that modulates HDL metabolism./ Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ.// Nat Genet. -1999-Р.21-Р.424–428. CrossRefMedlineGoogle Scholar
Hirata K. Cloning of a unique lipase from endothelial cells extends the lipase gene family./ Hirata K, Dichek HL, Cioffi JA, Choi SY, Leeper NJ, Quintana L, Kronmal GS, Cooper AD, Quertermous T. // J Biol Chem. -1999-№ 274-Р.14170–14175.
Ehnholm C. Purification from human plasma of a heparin-released lipase with активность against triglyceride and phospholipids./ Ehnholm C, Shaw W, Greten H, Brown WV. // J Biol Chem.- 1975-№ 250-Р.6756–6761.
McCoy MG. Characterization of the lipolytic активность of endothelial lipase./ McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ. // J Lipid Res. -2002-№43-Р.921–929.
Ji Z-S. Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture. / Ji Z-S, Lauer SJ, Fazio S, Bensadoun A, Taylor JM, Mahley RW. //J Biol Chem. -1994-№ 269-Р.13429–13436.
Krapp A. Hepatic lipase mediates the uptake of chylomicrons and beta-VLDL into cells via the LDL receptor-related protein (LRP)./ Krapp A, Ahle S, Kersting S, Hua Y, Kneser K, Nielsen M, Gliemann J, Beisiegel U. // J Lipid Res. -1996-№ 37-Р.926–936. Abstract
Ji Z-S. Heparan sulfate proteoglycans 6articipate in hepatic lipase and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins./ Ji Z-S, Dichek HL, Miranda RD, Mahley RW. // J Biol Chem.- 1997-№ 272-Р.31285–31292.
Fuki IV Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway./ Fuki IV, Blanchard N, Jin W, Marchadier DH, Millar JS, Glick JM, Rader DJ. // J Biol Chem.- 2003-№278-Р.34331–34338
Andres-Blasco Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis./ Andres-Blasco , Herrero-Cervera A, Vinue A, Martinez-Hervas S, Piqueras L, Sanz MJ, Burks DJ, Gonzalez-Navarro H.// J Endocrinol. -2015.-№227(3)-Р.179-91.
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