State of biochemical system of white rat’s blood in conditions of alcoholic hepatic injury and preventive action metadoxine

O. V. Karpova, G. M. Shayakhmetova, A. K. Voronina, N. Y. Golovenko

Abstract


It was developed model of alcoholic hepatitis by intragastric administration of 40 % ethanol at a dose of 7 ml/kg body weight of male Wistar rats for 7 days. As a biochemical marker of alcoholic hepatitis were used indicators of cytolytic syndrome (activity of alanine aminotransferase, aspartate aminotransferase, catalase), cholestatic syndromes (alkaline phosphatase, gamma glutamyl transpeptidase) and lipid exchange (levels of cholesterol, triglycerides). It was shown that metadoxine (ionic salt of pyridoxine and pyroglutamic acid), which was administered preventively intragastrically at a dose of 90 mg/kg 30 min prior to the administration of alcohol, normalized activity of aspartate aminotransferase and catalase; gamma-glutamyl transpeptidase; triglycerides. The lack of a positive influence of metadoxine on the other studied biochemical blood parameters indicatives that mechanisms of development of alcoholic hepatitis and course of its are different. It is assumed that the hepatoprotective effect of the drug is realized through antioxidant mechanism.


Keywords


metadoxine; alcoholic hepatitis; hepatic protector

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GOST Style Citations






DOI: https://doi.org/10.24959/89816

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)