New research efficiency gel containing an extract of oak bark and extract of aloe under condition protamine periodontal

N. A. Tsubanova, N. V. Hohlenkova, D. S. Zhurenko, Imamuzo Mathew Iroko

Abstract


This article investigates gum protector with new gel contains extract of oak bark and aloe under the experimental periodontitis. Studies were conducted on rats, which reproduce protamine periodontitis. In blood leukocytes and investigated the contents of the indicator erythrocyte sedimentation rate (ESR). In homogenate ash measured elastase activity, catalase, glutathione content was determined and reagents tiobarbituric acid. As the comparator we used metrogyl denta. It was established that the new gel at the drug affects the comparison of clinical parameters protamine periodontitis (redness, swelling, erosive and necrotic changes). Gel containing oak bark extract and aloe extract has a strong anti-inflammatory effect, reducing leukocytosis and ESR. Significant advantages of the new gel is its ability to influence the pathogenesis of periodontitis unlike Metrogyl gel found to influence the activity of elastase, catalase and glutathione indicators and reagents tiobarbituric acid is the reactant.


Keywords


gel; oak extract; aloe extract; protamіne periodontitis

References


Бусло А.М. Оптимізація комплексного лікування хворих на хронічний генералізований пародонтит з використанням гінгівостеопластики та поліпептидних препаратів. / А.М. Бусло. Автореферат десерт. на здобуття наук. ст. к. мед. н. Полтава. -2007.- 17с.

Компендиум 2011 – лекарственные препараты / Под ред. В.Н. Коваленко, А.П. Викторова. – К.: МОРИОН, 2011. – С.Л1009-1010.

Экспериментальное обоснование применения препаратов нанозолота для лечения заболеваний пародонта / А.В. Борисенко, О.Б. Ткач, О.В. Линовицкая и др. // Стоматолог-практик.- 2014.- №1(239).- С.58-62.

Стефанів І.В. Вплив стоматологічної настойки «Каcдент» на моделі сто-матиту у щурів / І.В. Стефанів, Л.В. Яковлєва, С.А. Гращенкова // Клінічна фармація, фармакотерапія та медична стандартизація. – 2014. - № 1(22). – С. 23-29.

Acutissimanide, a new lignan with antioxidant activity isolated from the bark of Quercus acutissima Carruth / X.L. Zeng, G.M. Fu, K. Tian et al. // Nat Prod Res. –2014. – Vol. 28(17). –Р.1364-1370.

Galvão-Moreira L.V. Oral microbiome, periodontitis and risk of head and neck cancer / L.V. Galvão-Moreira, M.C.da Cruz // Oral Oncol. – 2016. –Vol.53. –Р.17-19.

Gingival crevicular fluid as a source of biomarkers for periodontitis / S.P. Barros, R. Williams, S. Offenbacher et al. // J Periodontol. – 2016. – Vol.70(1). – 53-64.

Hajishengallis G. Imunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response / G. Hajishengallis // Trends Immunol. – 2014. – Vol. 35(1). – P.3-11.

Levels of IL-8,IL-10 in patients with chronic periodontitis and coronary heart disease / X.J. Bing, X.J. Sun, G.H. Shen et al. // Shanghai Kou Qiang Yi Xue. – 2015. – Vol.24(5). – Р.598-601.

Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases / A. Varela-López, P. Bullón, F. Giampieri et al. // Antioxidants (Basel). – 2015. – Vol. 4(3). –Р. 447-481.

Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease / А. Varela-López, J.L. Quiles, M. Cordero et al. // Antioxidants (Basel). – 2015. – Vol.4(2). –Р.322-344.

Periodontitis Awareness Amongst General Public: A Critical Systematic Review to Identify Gaps of Knowledge / P. Varela-Centelles, P. Diz-Iglesias, A. Estany-Gestal et al. // J Periodontol. –2015. – Vol. 6. – Р.1-19.


GOST Style Citations






DOI: https://doi.org/10.24959/89817

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)