Influence of Citrullus cologynthis (L.) shrad dry fruits extract on pancreas β-cells viability

Authors

  • G. R. Lamazyan O.O.Bohomolets National Medical University, Ukraine
  • M. M. Guzyk Palladin Institute of Biochemistry of NAS of Ukraine, Ukraine
  • T. M. Kuchmerovska Palladin Institute of Biochemistry of NAS of Ukraine, Ukraine

DOI:

https://doi.org/10.24959/ubphj.16.24

Keywords:

Citrullus colocynthis (L.), diabetes mellitus, β-cells viability

Abstract

The study investigated the ability of Citrullus colocynthis dry fruits extract to modulate survival of RIN-m5F cells in vitro. Various concentrations of Citrullus colocynthis had no toxic effect on the cells viability. Exposure of β-cells to high glucose concentration and prooxidant agents like tert-butylhydoperoxide and oleic acid had cytotoxic effects on their viability. Citrullus colocynthis protected cells against investigated agents action. Positive effect of Citrullus colocynthis could be associated with its direct modulatory action on regeneration and functional normalization of pancreas β-cells or/and indirectly through metabolic and antioxidant effects of Citrullus colocynthis constituents. Our findings provide important feasible data for utilizing Citrullus colocynthis for treatment of diabetes mellitus.

Author Biography

G. R. Lamazyan, O.O.Bohomolets National Medical University

Відділ біохімії вітамінів і коензимів,

провідний науковий співробітник

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Published

2016-04-12

Issue

No. 2(43) (2016)

Section

Pharmacology and biochemistry

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