Influence of Citrullus cologynthis (L.) shrad dry fruits extract on pancreas β-cells viability

G. R. Lamazyan, M. M. Guzyk, T. M. Kuchmerovska

Abstract


The study investigated the ability of Citrullus colocynthis dry fruits extract to modulate survival of RIN-m5F cells in vitro. Various concentrations of Citrullus colocynthis had no toxic effect on the cells viability. Exposure of β-cells to high glucose concentration and prooxidant agents like tert-butylhydoperoxide and oleic acid had cytotoxic effects on their viability. Citrullus colocynthis protected cells against investigated agents action. Positive effect of Citrullus colocynthis could be associated with its direct modulatory action on regeneration and functional normalization of pancreas β-cells or/and indirectly through metabolic and antioxidant effects of Citrullus colocynthis constituents. Our findings provide important feasible data for utilizing Citrullus colocynthis for treatment of diabetes mellitus.


Keywords


Citrullus colocynthis (L.); diabetes mellitus; β-cells viability

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References


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DOI: https://doi.org/10.24959/89819

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)