Research of pharmacological properties of Lamium album L. herb complexes
DOI:
https://doi.org/10.24959/ubphj.16.37Keywords:
white dead-nettle, antibacterial activity, sedative activity, anti-hypoxic activityAbstract
The antibacterial properties of lipophilic, phenolic complexes and dry extract and sedative activity of dry extract obtained from Lamium album (white dead-nettle) herb have been investigated. It is established that white dead-nettle dry extract shows weak, and complexes extracted with chloroform and ethyl acetate – a strong antibacterial activity against S. aureus. As for P. aeruginosa highest activity shows the phenolic complex, for C. albicans – lipophilic complex of L. album herb. Dry extract of white dead-nettle herb shows psycho-sedative properties at a dose of 100 mg/kg, and the tendency to anti-hypoxic and reduce anxiety action at a dose of 10 mg/kg. The dry extract exhibits greater degree of the discovered properties than the reference drug Alora®. Investigated complexes are promising targets for further study of pharmacological mechanisms of antibiotic, depressive and cerebroprotective activity.
References
Гончаров, О. В. Дослідження фенольних сполук трави кропиви глухої білої та кропиви глухої пурпурової / О. В. Гончаров, А. М. Ковальова, О. В. Горяча // Теоретичні та практичні аспекти дослідження лікарських рослин : матеріали І міжнар. наук.-практ. Internet-конф., м. Харків, 20-21 берез. 2014 р. – Х. : Вид-во НФаУ, 2014. – С. 69-70.
Ковальова, А.М. Дослідження компонентного складу ефірної олії квіток Lamium album / А.М. Ковальова, Я.С. Колісник, О.В. Гончаров, Т.В. Ільїна // Запорожский медицинский журнал. – 2012. – №3 (72). – С.74-75.
Методики и основные эксперименты по изучению мозга и поведения / Я. Буреш, О. Бурешова, Д.П. Хьюстон. – М.: Высшая школа. – 1991. – С. 119-122.
Руководство по проведению доклинических исследований лекарственных средств / Под ред. докт. мед. наук А.Н. Миронова. – Часть первая. – М.: Гриф и К, 2012. – 944 с.
Bubueanu, C. Antioxidant activity of butanolic extracts of Romanian native species – Lamium album and Lamium purpureum / C. Bubueanu, C. Gheorghe, L. Pirvu, G. Bubueanu // Romanian Biotechnological Letters. – Vol. 18, No. 6. – 2013. – Р. 8855-8862.
Grundmann, O. Anxiolytic effects of a passion flower (Passiflora incarnata L.) extract in the elevated plus maze in mice / O. Grundmann, C. Wähling, C. Staiger, V. Butterweck // Pharmazie. – 2009. – № 64(1). – Р. 36-64.
Ochkur, O. Amino acids and monosaccharides composition of white dead-nettle (Lamium album L.) herb extract / O. Ochkur, A. Kovalyova, O. Goncharov, A. Komisarenko // The Pharma Innovation Journal. – 2015. – 4(3). – P. 45-48.
Paduch, R. Lamium album extracts express free radical scavenging and cytotoxic activities / R. Paduch, G. Matysik, M. Wójciak–Kosior // Polish J. of Environ. Stud. – 2008. – Vol. 17, No. 4. – P. 569-580.
Soulimani, R. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse / R. Soulimani et al. // J. Ethnopharmacol. – 1997. – №57 (1). – Р. 11-20.
Yalçin, F.N. Ethnobotany, pharmacology and phytochemistry of the genus Lamium (Lamiaceae) scientific review / Funda N. Yalçin, Duyugu Kaya // Fabad J. Pharm. Sci. – 2006. – 31. – Р. 43-52.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
