Dexamethasone effect on the insulin resistance development and endothelial function under high-fructose diet in rats

A. L. Zagayko, T. A. Briukhanova

Abstract


The work is devoted to the results of the study of endothelium functional state changes in the rat’s blood under different experimental models of insulin resistance - in particular, modeled by hypercaloric diet with high fructose content or hypercaloric diet with high fructose and daily intraperitoneal injections of dexamethasone. It is shown that the pathological changes endothelial function markers have significant group differences depending on the model.


Keywords


insulin resistance; endothelial dysfunction; nitric oxide system

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GOST Style Citations






DOI: https://doi.org/10.24959/89431

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)