Dexamethasone effect on the insulin resistance development and endothelial function under high-fructose diet in rats

Authors

  • A. L. Zagayko National University of Pharmacy
  • T. A. Briukhanova National University of Pharmacy

DOI:

https://doi.org/10.24959/ubphj.16.41

Keywords:

insulin resistance, endothelial dysfunction, nitric oxide system

Abstract

The work is devoted to the results of the study of endothelium functional state changes in the rat’s blood under different experimental models of insulin resistance - in particular, modeled by hypercaloric diet with high fructose content or hypercaloric diet with high fructose and daily intraperitoneal injections of dexamethasone. It is shown that the pathological changes endothelial function markers have significant group differences depending on the model.

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Published

2016-06-13

Issue

Section

Pharmacology and biochemistry