Effect of the derivative of 2-benzamido-2-(2-oxoindolin-3-iliden) acetic acid on the activity of free-radical processes in traumatic brain injury
DOI:
https://doi.org/10.24959/ubphj.16.46Keywords:
derivative of 2-benzamido-2-(2-oxoindolin-3-iliden) acetic acid, mexidol, traumatic brain injury, lipid and protein peroxidation, antioxidant system, energy metabolismAbstract
In experiments on adult laboratory rats the effect of the derivative of 2-benzamido-2-(2-oxoindolin-3-iliden) acetic acid under the symbol ZNM on the activity of the lipid and protein peroxidation and antioxidant system in blood plasma and brain, as well as on the activity of the key enzyme of energy metabolism succinate dehydrogenase in the brain of animals with a closed traumatic brain injury (TBI) of moderate severity in comparison with the reference drug mexidol was investigated. It was established that ZNM not significantly concedes to the action of mexidol in its cerebroprotective on antioxidant properties under the conditions of TBI, contributing to normalization of the prooxidant-antioxidant balance in the blood plasma and brain of rats, as well as improving the energy metabolism in the cells of the central nervous system.
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