Oxidative stress correction with metabolic preparations, new possibilities of antioxidant protection in primary glaucoma

I. N. Mikheytseva, V. N. Yelskiy

Abstract


There were studied antioxidant action of water-soluble form of quercetin – corvitin and melatonin in rabbits with glaucoma model. It was shown intravenous injections of corvitin essentially decreased oxidative stress in animals with advanced stage of experimental glaucoma. Prophylactic-protective apply of melatonin on the basis of model induction in significant degree protected oxidative stress development.


Keywords


quercetin; melatonin; glaucoma; oxidative stress

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References


Краморенко Ю.С. Эмоксипин в лечении первичной глаукомы /Краморенко Ю.С., Добрица Т.А., Иманбаева З.А., Егоров Е.А. // Вестн. офтальмол. - 1992. - № 1. - С. 14-15. 17.

Михейцева И.Н. Оксидативный стресс и эндотелиальная дисфункция как патогенетические факторы в глаукомном процессе/Михейцева И.Н.// Патологія. – 2008. – т.5, №3. – С.125-126

Мойбенко А.А. Эффективность водорастворимой формы кверцетина (Корвитина) при лечении острого коронарногосиндрома с элевацией сегмента ST / Мойбенко А.А., Пархоменко А.Н., Кожухов С.Н.// Журн.АМН України – 2003. – Т.9, № 2. – С.361-370.

Мошетова Л.К. Лютеин-комплекс в лечении глаукомной оптической нейропатии/ Мошетова Л.К., Алексеев И.Б., Ивашина А.В.//Клиническая офтальмология – 2005. - т.6, № 2. - С. 67-69.

Патент України №61478 Спосіб моделювання адреналін-індукованої глаукоми у кролів/ Михейцева І.М. Опубл. 25.07.11, Бюл.№14.

Филина А.А. Антиоксидантная терапия первичной глаукомы/ Филина А.А.//Вестник офтальмол. – 1994. – т. 110, №1. – С. 33 — 35.

Ansari M.A. Protective effect of quercetin in primary neurons against Abeta (1-42): relevance to Alzheimer’s disease/ Ansari M.A., Abdul H.M., Joshi G. et al. // J. Nutr. Biochem. – 2009. – v.20, №4. – Р.269-275.

Bonnefont-Rousselot D. Melatonin: action as antioxidant and potential applications in human disease and aging/ Bonnefont-Rousselot D., Collin F.//Toxicology. – 2010. – v.278. – P.55-67.

Evans S.C. Ophthalmic nutrition and prevention of eye disorder and blindness/ Evans S.C. // Nutrition Metabolism - 1977. – v. 21. – P. 268-272.

Ferreira S.M. Oxidative stress markers in aqueous humor of glaucoma patients/ Ferreira S.M., Lerner S.F., Brunzini R. et al.//Am J Ophthalmol. – 2004. – v.137. - P.62–69.

Flammer J. Glaucomatous optic neuropathy: a reperfusion injury/ Flammer J //Klin Monatsbl Augenheilkd. – 2000. - v.218. P.290–291.

Flammer J. What is the present pathogenetic concept of glaucomatous optic neuropathy? /Flammer J., Mozaffarieh M.// Surv Ophthalmol. – 2007. - v.52. –P.162–173.

Gherghel D. Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma/ Gherghel D., Griffiths H.R., Hilton E.J. et al.//Invest Ophthalmol Vis Sci. – 2005. – v.46. – P.877–883.

Harwood M. A critical review of the data related to the safety of qurcetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties/ Harwood M., Danielewska-Nikiel B., Borzelleca J.F. et al. // Food Chem Toxicol. - 2007. – v.45. – P.2179-2205.

Izzotti A. The role of oxidative stress in glaucoma/ Izzotti A., Bagnis A., Sacca S.C. //Mutat Res. – 2006. - v.612. - P.105–14.

Krishna S.M. Vitamin A and primary glaucoma/ Krishna S.M., Shukla P.K. // J. Glaucoma – 1982. – v. 4. – P. 226-227.

Mozaffarieh M. Oxygen and blood flow: players in the pathogenesis of glaucoma/Mozaffarieh M., Grieshaber M., Flammer J.// Mol Vis. – 2008. – v.14. – P. 224–233.

Reiter R.J. Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging / R.J.Reiter, D.X.Tan, L.C.Manchester, M.R.El-Sawi // Ann. NY Acad. Sci. – 2002. – Vol. 959. – P. 238-250.

Reiter R.J. Melatonin: Lowering the High Price of Free radicals / Reiter R.J. // News Phisiol. Sci. –2000. –Vol. 15. –P. 246-250.

Ritch R. Potential role gingo biloba extract in the treatment of glaucoma/Rithc R.// Med Hypotheses - 2000. – v.54, №2. – Р.221- 235.

Sacca S.C. Glaucomatous outflow pathway and oxidative stress/ Sacca S.C., Izzotti A., Rossi P., Traverso C.// Exp Eye Res. – 2007. – v.84. - P.389–399.

Tezel G. Oxidative stress in glaucoma neurodegeneration: mechanism and consequences/ Tezel G. // Prog. Retin Eye Res. – 2006. – v.25, №5 – P.490-513.

Vauzour D. The neuroprotective potential of flavonoids: a multiplicity of effects/ Vauzour D., Vafeiadou K., Rodriguez-Mateos A. et al.// Genes Nutr. – 2008. - №3. – Р.115-126.


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DOI: https://doi.org/10.24959/89400

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)