Protein factors of oxidative stress and atherogenesis in patients with arterial hypertension
Keywords:arterial hypertension, atherogenesis, oxidative stress, paraoxonase-1, myeloperoxidase
The aim of this study was to evaluate the protein components of HDL in patients with arterial hypertension (AH). The study included 30 patients (mean age of 47.4±3.3 years) with AH 2 grade. The accumulation of carbonyl oxidation protein products in blood, HDL and LDL eventually results in oxidative modification of HDL and LDL, and loss of its functional properties. The activity of HDL-associated enzymes (PON1 and MPO) is the most informative indicator of functional state of HDL, and not the level of HDL-Cholesterol. Changes of MPO and PON1 activity may serve as a useful marker of dysfunctional HDL. Our evaluation showed a significant decrease of PON1 activity and increase of MPO activity that may contribute to the HDL oxidation, irrespective of HDL-Cholesterol levels. Demonstrated changes in the functional state of HDL, in our opinion, create a predisposition to development and progression of atherosclerosis in patients with AH.
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