Investigation of the effects of stevia and vaccinum from leaeves extract on the performance of an diabetes mellitus
DOI:
https://doi.org/10.24959/ubphj.16.52Keywords:
stevia leaf extract (Stevia rebaudiana Bertoni), vaccinum leaf extract (Vaccinum myrtillus), type 2 diabetes, insulin resistance, dexamethazoneAbstract
The study of the investigation of influence of extract from leaves of stevia and vaccinum on the expression of insulin resistance. Keeping animals on high-calorie diet with the additoin of fructose causes complex metabolic disordes specific to metabolic syndrome anf type 2 diabetes. It was found that the antioxidation action and hypoglycemic effect of the extract from of stevia leaves, while the use of extract from vaccinum under idential experimental condition, is manifested in more antioxidation action. Recommended joint use of the studied extracts in the complex treatment of diabetes 2-type.
References
Барчук О. З. Визначення вмісту БАР в екстрактах з листя чорниці звичайної / О. З. Барчук, Л. В. Вронська // Фармакологічний часопис. ‒ 2012. ‒ №1 . ‒ С. 60‒63.
Зворська О. Чорниця звичайна (Vaccinіum myrtillus L.) ‒ перспективна речовина для одержання лікарських засобів / О. Зворська, Т. Грошовий // Фармакологічний часопис. ‒ 2009. ‒ № 3. ‒ С. 29‒33
Ильин А.В. Гликозилированный гемоглобин как ключевой параметр при мониторинге больных сахарным диабетом / А. В. Ильин, М. И. Арбузова, А. П. Князева // Сахарный диабет. ‒ 2008. ‒ № 2. ‒ С. 60‒64.
Ивашкин В.Т. липотоксичность и метаболические нарушения при ожирении / В. Т. Ивашкин // Гастроентерология, гепатология, колопрология. ‒ 2010. ‒ Т. 2, № 1. ‒ С. 4‒13.
Рязанова Т.К. Фармакологическое исследование плодов и побегов черники обыкновенной / Т. К. Рязанова // Фундаментальные исследования. ‒ 2013. ‒ № 8, Ч. 5. ‒ С. 1136‒1140.
Макарова М. Н. Антииабнтическая активность флавоноидов и их комбинаций с антиоксидантами / М. Н. Макарова, В. Г. Макаров // Фармація. ‒ 2004. ‒ № 2. ‒ С. 30‒32.
Стальная И. Д. Метод определения ТБК- АП с помощью биобарбитуровой кислоты / И. Д. Стальная, Т. Г. Гаришвили // В кн. Современные методы в биологии / под ред. В. Н. Ореховича. ‒ М.: Медицина, 1977. ‒ С. 66‒68.
Строев Е.А. Практикум по биологической химии / Е.А. Строев, В. Г. Макарова. ‒ М.: Высш. шк., 1986. ‒ 231 с.
Энциклопедия народной медицины /укл і відп зед. О. Михайлевский. ‒ Львів: вид-во "Сполом". ‒ 2005. ‒ Т. 1. ‒ 1284 с.; Edwin J. Diabetology ang Herbal Medicine / J. Edwin, B. Siddaheswar, C. Dharam // IJPT. ‒ 2008. ‒ Vol. 7. ‒ P. 97‒108.
Artoni S. Effects of stevia, aspartate, and sucrose on food intake, satiety, and postprandial glucose and insulin levels / S. D. Artoni, C. K. Martin, H. Han et al. // Appetite. ‒ 2010. ‒ Vol. 55, № 1. ‒ Р. 37‒43.
Baby Joseph. In sight the hypoglycaemic effect of traditional indian herbs used the teratment of diabetes / Joseph Baby, D. Jini Rjmp // IJPT. ‒ 2011. ‒ Vol 4. ‒ P. 352‒375.
Buren J. Dexamethasone decreases GLUT 1 and GLUT4 content in primary cultured rat adipocytes / J. Buren, J. Ereksson // Diabetol. ‒ 1999. ‒ Vol. 42, № 1. ‒ Р. 170.
Chen T. H. Mechanism of the hypoglycemic effects of stevioside, a glycoside of stevia rebaudiana / T. H. Chen, S. C. Chen, Chan P et al. // Planta Med. ‒ 2005. ‒ Vol. 71, № 2. ‒ Р. 108‒113.
Gregersens S. Antihyperglycemic effects of stevioside in type 2 diabetic subjects / S. Gregersens, P. B. Jeppesen, J. J. Holst // Metabolism. ‒ 2004. ‒ Vol. 53, № 1. ‒ Р. 73‒76.
European convention for the protection of vertebrate animals used for experimental and other scientific purposes ‒ Strasbourg: Council of Europe, 1986. ‒ 53 p.
Relationships among insulin resistance, obesity, diagnosis of the metabolic syndrome and cardio-metabolic risk / Salamar M. R. [et al.] // Diabetes and Cardiovasc. Dis. Res. ‒ 2014. ‒ Vol. 8, № 2. ‒ Р. 109‒116.
Severino C. Low-dose dexamethosone in the rat: a model to study insulin resistance / C. Severino, P. brizzi, A. Solinas et al. // Amer/ J. of Physiol. ‒ 2012. ‒ Vol. 283, № 2. ‒ Р. 367‒373.
The role of the insulin resistance in the pathogenesis of atherosclerotic cardiovascular diseases: an uptated review / Reddy K. J. [et al.] // J. of Carviovasc. Med. ‒ 2010. ‒ Vol. 11, № 9. ‒ Р. 633‒647.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).