Studying of stability of tablets on the basis of the substance ademetionine 1,4-butandisulfonate

K. S. Burdak, T. H. Yarnyh, M. I. Borshchevska, V. A. Konovalenko

Abstract


The essential part of development of composition and technology of medicines is research of its stability. It allows to assert and to overbear accuracy of choosing of adjuncts, ways and conditions of getting a medicinal drug, to lay down definitive parameters and expiry date. By using the Karl Fischer method (SPhU* 2.5.12) and liquid chromatography (SPhU* 2.2.29) it was found that the optimal environment for production of tablets on the basis of ademetionine 1,4-butandisulfonate is 20° C and the humidity must be no more than 20%. These very conditions make possible to save the stability of medicinal drug according to such parameters as water content, determination of accompanying impurities, quantitative determination and content of S,S-isomere within 12 months.


Keywords


ademetionine 1,4-butandisulfonate; shelf life; optimum conditions

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GOST Style Citations






DOI: https://doi.org/10.24959/89418

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)