Oxydation of 2-(5-(quinoline-2-yl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its esters to 3-ylsulfonyl-, and 3-ylsulfinylderivatives
DOI:
https://doi.org/10.24959/ubphj.16.56Keywords:
1, 2, 4-triazole, synthesis, chemical properties, HPLC-MSAbstract
One of priority tasks of modern pharmaceutical science is the synthesis of biologically active compounds and creation of new highly effective drugs which could compete with expensive imported medicines. The heterocyclic systems, including a 3-thioderivatives of 1,2,4-triazoles containing quinoline radical in the fifth position of 1,2,4-triazole cycle cause the interest in this branch of chemistry. The nucleus of 1,2,4-triazole is a structural fragment of many synthetic drugs with antifungal (fluconazole, itraconazole) antidepressant (trazodone, alprazolam), antiviral (thiotriazolin), hepatoprotective and wound healing activities. High biological properties also have found in substances containing quinoline substituents. So, the synthesis of new molecules in the range of 1,2,4-triazole derivatives is prospective and actual direction of science. It has theoretical and practical significance.
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