Circadian characteristics of the glutargin influence on protein and purine metabolism under the conditions of chronodeterminated acetaminophen hepatitis in rats

Authors

  • K. O. Kalko National University of Pharmacy, Ukraine
  • S. M. Drogovoz National University of Pharmacy, Ukraine
  • S. Yu. Shtrigol National University of Pharmacy, Ukraine
  • A. V. Kononenko National University of Pharmacy, Ukraine
  • V. A. Ulanova National University of Pharmacy, Ukraine
  • T. K. Yudkevich National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ubphj.16.58

Keywords:

hepatic, protein metabolism, glutargin

Abstract

The aim of the work was to determine the circadian characteristics of the glutargin influence on protein and purine metabolism under the conditions of chronodeterminated acetaminophen hepatitis in rats. Typical phatology was simulating by acetaminophen administration (dose of 1000mg/kg on the rat) in such periods and hours of the day and night as morning (9.00), afternoon (15.00), evening (21.00), and night (3.00). The glutargin was administration in medical-preventive regime, that is an hour before the acetaminophen administration and two hours after in dose of 135 mg/kg on the rat. As the results of this investigations was determined that glutargin administration against the background of the chronodeterminated acetaminophen hepatitis hadn’t been characterized by changes of total protein and albumin contents, while the increasing level of carbamide was depending on circadian group of medicament (on 10-33%) and decreasing level of uric acid was only in medicament of 9.00 am group (on 24%).

Obtained results should be taken into consideration in developing of glutargin chronoportrait.

References

Біохімія: підручник / за загальною редакцією проф. А. Л. Загайко, проф. К. В. Александрової. – Х.:Вид-во «Форт», 2014 – 728 с.

Доклінічні дослідження лікарських засобів: Методичні рекомендації / За ред.: член-кор. АМН України О. В. Стефанова. – К.: Авіценна, 2001. – 528 с.

Дроговоз С. М. Фармакология в помощь студенту, провизору и врачу: учебник-справочник / С. М. Дроговоз, С. Ю. Штриголь, Щекина Е.Г. – Х.: Титул, 2013. – 900 с.

Камышников, В. С. Справочник по клинико-биохимической лабораторной диагностике: в 2т./ В. С. Камышников.− Мн.: Беларусь, 2000. – Т.1. – 495 с.

Семененко С. Б. Особливості структури хроноритмів екскреторної функції нирок за умов гіперфункції шишкоподібної залози / С. Б. Семененко // Буковинській медичний вісник. – Т. 18, № 2 (70). – 2014− С. 99-101.

Соломенник Е.В. Влияние препарата глутаргин на клинико-биохимические показатели у больных острым вирусным гепатитом А / А. О. Соломенник, Е. В. Юрко, Е. И. Могиленець, К. И. Никитина // Актуальні питання фармацевтичної і медичної науки та практики. − 2010 − № 4. – С. 107 − 109

Реброва, О. Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA – 3-е изд. / О.Ю. Реброва. – М. :МедиаСфера, 2006. – 312 с.

Рыболовлев Ю.Р. Дозирование веществ для млекопитающих по константе биологической активности / Ю.Р. Рыболовлев, Д.С. Рыболовлев // Доклады АН СССР. – 1979. – Т. 247, №6 – С. 1513 – 1516.

Руководство по проведению доклинических исследований лекарственных средств / Под. ред. док. мед. наук. А. Н. Миронова − М.: Гриф и К, 2012. – Ч.1. − 944 с.

Матвеев А.В. Гепатопротекторы Анализ международных исследований по препаратам группы лекарств для печени / А. В. Матвеев. – Симферополь: ИТ «Ариал», 2013 – 384 с.

Хронофармакология наглядно (Хронофармакология в таблицях и рисунках): Справочник – учебное пособие / С.М. Дроговоз [и др.]− Х.: Титул, 2014. − 128 с.

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Published

2016-08-15

Issue

No. 4(45) (2016)

Section

Pharmacology and biochemistry

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