The influence of the rare-earth metals nanoparticles on the rat's males reprductive function in the descending stage of ontogenesis

Authors

  • N. O. Karpenko State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • Ye. M. Korenieva State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • E. Ye. Chystiakova State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • N. P. Smolienko State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • I. O. Bielkina State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • N. Yu. Seliukova State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • S. P. Kustova State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • M. O. Boiko State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”, Ukraine
  • Yu. B. Larianovska National University of Pharmacy, Ukraine
  • V. K. Klochkov STC “Institute for Scintillation Materials, NAS of Ukraine”, Ukraine
  • N. S. Kavok STC “Institute for Scintillation Materials, NAS of Ukraine”, Ukraine

DOI:

https://doi.org/10.24959/ubphj.16.59

Keywords:

nanoparticles of Gadolinium Ortovanadate, reproductive function, spermatogenesis

Abstract

The anti-aging effects of the rare-earth metals nanoparticles have been studied on the 18-21-month-old rat males. It was shown that the nanoparticles of Gadolinium Ortovanadate activated by Europium (GdVO4 : Eu3+ ) in a dose of 0,33 mg/kg during chronic using (70 days) have demonstrated the anti-aging effects on the old male’s reproductive function manifested by the increasing the sex hormone level and activating the spermatogenesis.

Author Biography

N. O. Karpenko, State Institution “Institute for endocrine pathology problems named after V. Ya. Danilevskyi NAMS of Ukraine”

 

 

References

Безруков, В. П. Влияние постарения населения на формирование потребностей в финансировании здравоохранения / В. П. Безруков // Материалы консульт. междунар. семинара. – М. : МЗМП РФ, 1995. – С. 149.

Бондаренко, В. А. Функция печени и андрогенный статус у мужчин с идиопатическими патоспермиями // В. А. Бондаренко, А. С. Минухин, Е. И. Скорня¬ков // Пробл. ендокрин. патології. – 2012. – № 2. – С. 15 –19.

Верткин, А. Л. Возрастной андрогенный дефицит и эректильная дисфункция / А. Л. Верткин, Д. Ю. Пушкарь – М. : Изд. группа «ГЭОТАР-Медиа», 2009 – 176 с.

Гланц, С. А. Медико-биологическая статистика / С. А. Гланц. – М. : Практика, 1998. – 459 с.

Дедов, И. И. Возрастной андрогенный дефицит у мужчин [Текст] / И. И. Дедов, С. Ю. Калинченко. — М. : Практ. медицина, 2006. – 240 с.

Доклінічні дослідження лікарських засобів : Метод. рекомендації// за ред. О. В. Стефанова. – К. : Авіцена, 2001. – 528 с.

Інтегральна оцінка репродуктивної функції самців лабораторних тварин / Н. О. Карпенко, В. В. Талько, С. Т. Омельчук [та ін.] // Укр. біофармацевтич. журн. – 2011. – Т. 13, № 2. – С. 64-68.

Куликовский, В. Ф. Частичный андрогенодефицит, остеопения и ранние нарушения микции у стареющих мужчин, связь явлений / В. Ф. Куликовский, Н. В. Олейник // Совр. наукоемкие технологии. – 2009. – № 6. – С. 48-49.

Пат. 2341528 RU, МПК C07F9/00. Оксованадиевый комплекс с глицином, проявляющий гипогликемическую активность [Електронний ресурс] / Е. Н. Вергейчик, О. В. Лапочкин, Л. Б. Губанова (RU) ; заявник та патентовласник ГОУ ВПО Пятигорская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию (RU). – № 2007116481/04 ; заявл. 02.05.07 ; опубл. 20.12.08. – Режим доступа : www.fips.ru

Сравнительная характеристика ванадий-содержащих соединений, обладающих инсулиноподобным действием / М. А. Голубев, В.К.Го¬родецкий, А.П.Аниськина // Вопр. мед. химии. – 2000. – № 2. –С.78-83.

Скальный, А. В. Химические элементы в физиологии и экологии человека [Електронний ресурс] / А. В. Скальный – Режим доступу : http://www.m-kat.ru/ebook.php?file=skalny.djvu&page=26

American Association of Clincal Endocrinologists. Medical Guidelines for Clinical Practice for the Management of Diabetes Mellitus: AACE Diabetes Mellitus Clinical Practice Guidelines Task Force // Endocrine Practice. – 2007. – Vol. 13, Suppl. 1. – P. 3-66.

Baran, E. Oxovanadium (IV) and oxovanadium(V) complexes relevant to biological systems // J. Inorganic Biochem. – Vol. 80, Issues 1–2. – P. 1–10.

Cam, M. C. Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?/ M. C. Cam, R. W. Brownsey, J. H. McNeill / Canad. J. Physiol. Pharmacol. – 2000. – Vol. 78, № 10.– P. 829-847.

Cam, М. С. Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?/ M. C. Cam, R. W. Brownsey, J. H. McNeill // Canad. J. Physiol. Pharmacol. –2000. – Vol. 78, № 10. – Р. 10-18.

Domingo, J. L. Vanadium: a review of the reproductive and developmental toxicity / J. L. Domingo // Reprod Toxicol. – 1996. – Vol. 10, № 3. – P. 175-82.

Effects of aging on food intake and body composition in rats / M. A. Thomas, H. B. Rice, D. Weinstock, R. L. Corwin // Physiol. Behav. – 2002. – Vol. 76, № 4-5. – P. 487-500.

Effects of vanadate on male rat reproductive tract histology, oxidative stress markers and androgenic enzyme activities/ A.K. Chandra, R. Ghosh, A. Chatterjee, M. Sarkar // J. Inorg. Biochem. – 2007. – Vol. 101, № 6. – Р. 944-956.

Marzban, L. Insulin-Like Actions of Vanadium: Potential as a Therapeutic Agent / L. Marzban, J. H. McNeill // J. Trace Elements in Experim. Med. – 2003. – Vol. 16. – P. 253–267.

Protection against vanadium-induced testicular toxicity by testosterone propionate in rats [Text] / A. K. Chandra, R. Ghosh, A. Chatterjee, M. Sarkar // Toxicol. Mech. Methods. – 2010. – Vol. 20, № 6. – Р. 306-315.

Testosterone levels and cognition in elderly men: a review / J. Holland [et al.] // Maturitas. – 2011. – Vol. 69, № 4. – P. 322-337.

Yeap, B. B. Hormones and health outcomes in aging men / B. B. Yeap // Exp. Gerontol. – 2013. – Vol. 11, № 2. – P. 251-270.

Downloads

Published

2016-08-15

Issue

No. 4(45) (2016)

Section

Pharmacology and biochemistry

License

Copyright (c) 2016 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).