Corrective influence food concentrate phenolic compounds of apples in experimental metabolic syndrome in syrian golden hamsters

T. O. Briukhanova, A. L. Zagayko


The article has presented the results of study appropriateness of use the food concentrate phenolic compounds of apple in experimental metabolic syndrome in Syrian golden hamsters. It was used epigallocatechin gallate like the medicine for the comparing. It was revealed that the food concentrate and EGCG correcting pathological changes carbohydrate and lipid metabolism, which are formed in a pathology model. Thus, the food concentrate phenolic compounds of apple has rendered more pronounced effect, which is obviously related to its complex antioxidant effects and normalization of antioxidant-prooxidant balance.


metabolic syndrome; the food concentrate phenolic compounds of apple; epigallocatechin gallate; insulin resistance


Teramoto T., Sasaki J., Ishibashi S., Birou S. Metabolic syndrome. Journal of atherosclerosis and thrombosis 2014; 21(1): 1-5.

Romeo G. R., Lee J., Shoelson S. E. Metabolic syndrome, insulin resistance, and roles of inflammation–mechanisms and therapeutic targets. Arteriosclerosis, thrombosis, and vascular biology 2012; 32(8): 1771-1776.

Otsuki M., Kitamura T., Goya K. Association of urine acidification with visceral obesity and the metabolic syndrome. Endocrine journal 2011; 58(5): 363-367.

Bondonno C. P. Flavonoid-rich apples and nitrate-rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial. Free Radical Biology and Medicine 2012; 52(1): 95-102.

Brown A. L. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. British journal of nutrition 2009; 101(06): 886-894.

Gómez-Guzmán M., Jiménez R., Sánchez M., Zarzuelo M. Epicatechin lowersblood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension. Free Radical Biology and Medicine 2012; 52(1): 70-79.

Jeong S. M., Kang M. J., Choi H. N., Kim J. H. Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutrition research and practice 2012; 6(3): 201-207.

Foster M. T. Solomon M. B., Huhman K. L., et al. Social defeat increases food intake, body mass, and adiposity in Syrian hamsters. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 2006; 290: R1284 - R1293.

Nistor A., Bulla A., Filip D.A., Radu A. The hyperlipidemic hamster as a model of experimental atherosclerosis. Atherosclerosis 1987; 68: 159 –173.

Taghibiglou C., Rashid-Kolvear R., Van Iderstine S.C., Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J. Biol. Chem. 2002; 277: 793 –803.

Chen W. Q. Zhao X. L., Wang D. L. Effects of epigallocatechin-3-gallate on behavioral impairments induced by psychological stress in rats. Experimental Biology and Medicine 2010; 235(5): 577-583.

Aguirre L. Beneficial effects of quercetin on obesity and diabetes. Open Nutraceuticals J. 2011; 4: 189-198.

Jian-Mei L. I. Chuang W. A. N. G., Qing-Hua H. U., Ling-Dong K. O. N. G. Fructose induced leptin dysfunction and improvement by quercetin and rutin in rats. Chinese Journal of Natural Medicines 2008; 6(6): 466-473.

Kawabata K., Kawai Y., Terao J. Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. The Journal of nutritional biochemistry 2010; 21(5): 374-380.

Panchal S. K., Poudyal H., Brown L. Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. The Journal of nutrition 2012; 142(6): 1026-1032. 16 Wein S., N. Behm, Petersen R. K., Kristiansen K. Quercetin enhances adiponectin secretion by a PPAR-γ independent mechanism. European Journal of Pharmaceutical Sciences 2010; 41(1): 16-22.

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