Experimental study of choleretic activity of the drug "Altsinara"
DOI:
https://doi.org/10.24959/ubphj.16.68Keywords:
"Altsinara", cholagogic properties, choleretic, middle effectivedoseAbstract
The results of preclinical studies of choleretic activity of the drug "Altsinara", tablets for oral administration of PJSC SIC "Borshchivskiy CPP".
The studies found that the impact on the various indicators in the studied doses Altsenara was diverse. Thus, in evaluating the cholagogic activity more effective dose was 100 mg/kg than 50 mg/kg. However, the effect on cholesterol, cholate-cholesterol ratio, reflecting the lithogenic properties of bile, dose of 50 mg/kg dose was significantly greater than 100 mg/kg and the reference drug "Allohol". According the results of the research by probit-analysis the ED50 of Altsinara for choleretic activity was calculated – 72,4 ± 11,0 mg/kg on the amount of active ingredients.
Thus, the results of the research indicate that the presence of choleretic properties of the test agent, especially true choleretic, is an important positive feature for perspective drugs of lipid-lowering action.
References
Доклинические исследования лекарственных средств: Методические ре-комендации / Под ред. А.В. Стефанова. – К: Авиценна, 2002. – 528 с.
Лапач С.Н. Статистические методы в медико-биологических исследова-ниях с использованием Excel / С.Н. Лапач, А.В. Чубенко, П.Н. Бабич – Киев: Морион, 2000. – 320 с.
Настанова СТ-Н МОЗУ 42-6.0:2008. Лікарські засоби. Належна лабо-раторна практика (видання офіційне) / О.Стефанов, Т. Бухтіарова, В. Коваленко та ін. – К.: Моріон, 2009. – С. 37-68.
Определение содержания желчных кислот и холестерина в желчи / В.П. Мирошниченко, Л.Л. Громашевская, М.Г. Касаткина и др. // Лаб. дело. – 1978. – № 3. – С. 149-153.
Орловская Т.В. Изучение желчегонной активности сухих экстрактов, полученных из корневищ и корней любистока лекарственного / Т.В. Орловская, С.Я. Овчинникова // Международный журнал прикладных и фундаментальных исследований. – 2014. – №1. – С. 118-119.
Прозоровский В.Б. Статистическая обработка результатов фармаколо-гических исследований / В.Б. Прозоровский // Психофармакология и биологическая наркология. – 2007. – Т. 7, № 3-4. – С. 2090-2120.
Реброва О.Ю. Статистический анализ медицинских данных. Примене-ние пакета прикладных программ STATISTICA. – 3-е изд. – Москва : МедиаСфера, 2006. – 312 с.
Руководство по проведению доклинических исследований лекарствен-ных средств. Часть первая / Под ред. А.Н. Миронова. — М.: Гриф и К, 2012. – 944 с
Скакун Н.П. Основы фармакологии желчевыделительного процесса : автореф. дис. на соиск. научн. степ. докт. мед. наук / Н.П. Скакун. – Львов, 1960. –24 с.
Скакун Н.П. Сравнительное действие атропина и метацина на внешне-секреторную функцию печени / Н.П. Скакун, А.Н. Олейник // Фармако-логия и токсикология. – 1967. – № 3. – С. 334-337.
Effect of artichoke extract (Cynara scolymus L.) on palmitic-1-14C acid ox-idation in rats / Z. Juzyszyn, B. Czerny, A. Pawlik, M. Drozdzik // Mol. Nutr. Food Res. – 2008. – Vol. 52 (5). – P. 589-594.
Effect of pretreatment with artichoke extract on carbon tetrachloridein-duced liver injury and oxidative stress / G. Mehmetcik, G. Ozdemirler, N. KocakToker et al. // Exp. Toxicol. Pathol. – 2008. – Vol. 60. – P. 475-480.
The study of the safety profile of “Altsinara” drug under the conditions of acute toxicity modeling / A. Tattis, I.A. Zupanets, I.A. Otrishko, Ie.F. Grintsov // Клінічна фармація. – 2015. – Т. 19, №3. – С. 44-47.
WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. – World Health Organization, 2007. – 118 p.
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