Aromatase inhibitors pharmacological importance

D. V. Lytkin, A. L. Zagayko

Abstract


This review is devoted to the different generations aromatase inhibitors characteristics, their place in clinical practice and in the cancer treatment. Drugs from this group are able to inactivate aromatase enzyme, and causes estrogen synthesis inhibition. High effective and selective aromatase inhibitors of 3rd generation, have recently entered the market, could compete with tamoxifen - "gold standard" of the breast cancer management. A successful clinical trials of letrozole and anastrozole have identified new approaches to the treatment of estrogen-dependent cancers and to the enlargement of the scope of these drugs using.

Keywords


aromatase inhibitors; letrozole; anastrozole

References


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GOST Style Citations






DOI: https://doi.org/10.24959/89411

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)