Metabolic effects of carnitine role in the development of pathologies and prospects for clinical application (review)
DOI:
https://doi.org/10.24959/ubphj.16.77Keywords:
carnitine, cardiomyopathy, insulin resistance, metabolic syndromeAbstract
In the literature review the generalized data about the metabolic role of carnitine in the biochemical processes, the consequences of carnitine deficiency and its contribution to the pathogenesis of the development pathologies, prospects for the use of carnitine in clinical practice.
References
Копелевич В. М. Витаминоподобные соединения L-карнитин и ацетил-L-карнитин: от биохимических исследований к медицинскому применению //Укр. біохім. журн. – 2005. – Т. 77. – №. 4. – С. 30-50.
Johri A. M. et al. Carnitine therapy for the treatment of metabolic syndrome and cardiovascular disease: Evidence and controversies //Nutrition, Metabolism and Cardiovascular Diseases. – 2014. – Vol. 24. – №. 8. – Р. 808-814.
Fukuda M. et al. Carnitine deficiency: Risk factors and incidence in children with epilepsy //Brain and Development. – 2015. – Vol. 37. – №. 8. – P. 790-796.
Paulson D. J. Carnitine deficiency-induced cardiomyopathy //Molecular and cellular biochemistry. – 1998. – Vol. 180. – №. 1-2. – P. 33-41.
Panchal S. K. et al. Modulation of tissue fatty acids by L-carnitine attenuates metabolic syndrome in diet-induced obese rats //Food & function. – 2015. – Vol. 6. – №. 8. – P. 2496-2506.
Dumas M. E., Kinross J., Nicholson J. K. Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease //Gastroenterology. – 2014. – Vol. 146. – №. 1. – P. 46-62.
Rebouche C. J. L‐Carnitine //Present Knowledge in Nutrition, Tenth Edition. – 2012. – P. 391-404.
Frenkel R. (ed.). Carnitine Biosynthesis Metabolism, and Functions. – Elsevier, 2012.
Mancuso C. et al. Natural substances and Alzheimer's disease: from preclinical studies to evidence based medicine //Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. – 2012. – Vol. 1822. – №. 5. – P. 616-624.
Wang S. et al. Primary carnitine deficiency cardiomyopathy //International journal of cardiology. – 2014. – Vol. 174. – №. 1. – P. 171-173.
El-Hattab A. W., Scaglia F. Disorders of carnitine biosynthesis and transport //Molecular genetics and metabolism. – 2015. – Vol. 116. – №. 3. – P. 107-112.
Flanagan J. L. et al. Role of carnitine in disease //Nutrition & metabolism. – 2010. – Vol. 7. – №. 1. – P. 1-14.
Marycz K. et al. Influence of functional nutrients on insulin resistance in horses with equine metabolic syndrome //Pak Vet J. – 2014. – Vol. 34. – P. 189-192.
Mohamed S. Functional foods against metabolic syndrome (obesity, diabetes, hypertension and dyslipidemia) and cardiovasular disease //Trends in Food Science & Technology. – 2014. – Vol. 35. – №. 2. – P. 114-128.
Zhang J. et al. L-carnitine ameliorated fasting-induced fatigue, hunger, and metabolic abnormalities in patients with metabolic syndrome: a randomized controlled study //Nutrition journal. – 2014. – Vol. 13. – №. 1. – P. 1-14.
Di Nicolantonio J. J. et al. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis //Mayo Clinic Proceedings. – Elsevier, 2013. – Vol. 88. – №. 6. – P. 544-551.
Violante S. et al. Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines //The FASEB Journal. – 2013. – Vol. 27. – №. 5. – P. 2039-2044.
Keung W. et al. Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice //Diabetes. – 2013. – Vol. 62. – №. 3. – P. 711-720.
Wasserstein A. G. L-Carnitine Supplementation in Dialysis: Treatment in Quest of Disease //Seminars in dialysis. – Blackwell Publishing Ltd, 2013. – Vol. 26. – №. 1. – P. 11-15.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
