Derivative of 4-(R-amino)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thioles, as a promising antibacterial and antifungal substance

Abstract

This article contains the results antimicrobial and antifungal activity 3-(alkylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-4-amines (1-6), N-R-eden-3-(nonylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-4-amines (7-9) and 2-((4-amino-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)-N’-
R-acetohydra-zides are studied the results by the method of “serial dilutions”. Compound 6 and 20 show the same antifungal activity with comparing fluconazole. A substance 3 (MIC of 31.25 mg/ml) is the most active compound on S. Aureus bacteria which was studied among 3-(alkylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles-4-amine (1-6). Replacing of hexyl radical in atom of sulfur to nonyl and injection in the molecule 3-(alkylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles-4-amine 4-methoxybenzyl-iden substitute (9) led to increasing antimicrobial activity (MIC 15.6 mg/ml).