Validation of assay method of amlodipine in tablets by liquid chromatography

L. S. Logoyda, D. B. Korobko

Abstract


The aim of this study was the validation of methods of quantitative determination of amlodipine in tablets by liquid chromatography. Methods: The chromatographic analysis was performed on amlodipine liquid chromatograph Agilent 1290 Infinity II LC System. Results: A validation of methods of quantitative determination of amlodipine by high performance liquid chromatography tablets has been performed. It was established that the method proves the requirements of the State Pharmacopoeia of Ukraine for the main validation parameters: specificity, accuracy, linearity, robasnist. Conclusion: The results obtained in this study clearly indicate that the developed HPLC method is fast, economical, simple, accurate and suitable for determination of amlodipine in medications.


Keywords


amlodipine; quantitative analysis; validation; chromatography; validation parameters

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GOST Style Citations


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DOI: https://doi.org/10.24959/89901

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)