Validation of assay method of amlodipine in tablets by liquid chromatography

Authors

  • L. S. Logoyda I. Ya. Horbachevsky Ternopil State Medical University, Ukraine
  • D. B. Korobko I. Ya. Horbachevsky Ternopil State Medical University, Ukraine

DOI:

https://doi.org/10.24959/ubphj.16.86

Keywords:

amlodipine, quantitative analysis, validation, chromatography, validation parameters

Abstract

The aim of this study was the validation of methods of quantitative determination of amlodipine in tablets by liquid chromatography. Methods: The chromatographic analysis was performed on amlodipine liquid chromatograph Agilent 1290 Infinity II LC System. Results: A validation of methods of quantitative determination of amlodipine by high performance liquid chromatography tablets has been performed. It was established that the method proves the requirements of the State Pharmacopoeia of Ukraine for the main validation parameters: specificity, accuracy, linearity, robasnist. Conclusion: The results obtained in this study clearly indicate that the developed HPLC method is fast, economical, simple, accurate and suitable for determination of amlodipine in medications.

References

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Державна Фармакопея України : в 3 т. / Державне підприємство «Український науковий фармакопейний центр якості лікарських засобів». – 2-е вид. – Харків: Державне підприємство «Український науковий фармакопейний центр якості лікарських засобів», 2014. – Т. 2. – 724 с.

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Published

2016-12-20

Issue

No. 6(47) (2016)

Section

Pharmaceutical chemistry and pharmacognosy

License

Copyright (c) 2016 National University of Pharmacy

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