Pathomorpological research of vaginal suppositories “klimedeks” in rats with the irrytative vaginitis

O. V. Dolzhykova, L. M. Maloshtan

Abstract


Vaginitis is one of the most common reasons of women during calls to the gynecologist. The best method of their treatment is vaginal suppositories that contain antibacterial and anti-inflammatory components. We have studied
vaginal suppositories “Klimedeks” in female-rats with experimental vaginitis caused by irritants mixture of a gum turpentine and dimethylsulfoxide. Treatment of vaginitis was 8 days. At 5th and 8th days animals were taken out
of the experiment by method of euthanasia and researched vaginal mucosa by histologically. Vaginal suppositories “Klimedeks” at the fifth day of the experiment positively impact on the mucosa of the vagina in 87.5 % female rats of the animals had no signs of damage and inflammation of the lining of the vagina and superior comparator vaginal tablets “Mikozhynaks” for therapeutic effect. On the eighth day of the experiment, 100 % structural and functional state of animals mucous membrane of the vagina fully recovered. Placebo did no positive impact on the vagina of rats.


Keywords


experimental vaginitis; postmortem study; vaginal suppositories; rats

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DOI: https://doi.org/10.24959/90048

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)