Particularity of oxidative processes in rats affected by carbon tetrachloride on the background intoxication of malathion

Authors

DOI:

https://doi.org/10.24959/ubphj.17.111

Keywords:

carbontetrachloride, malathion, rats, endogenous intoxication, free radical processes

Abstract

Topicality. The problem of the environment chemical pollution impact on the human body is one of the priority and not fully studied. Among the pollutants carbon tetrachloride malathion poses a significant reat – it is a factor of risk for many environmentally dependent diseases. There fore, it is important to study the characteristics and mechanisms of a mentioned xenobiotics combined action on the body .

Aim. To investigate the activity of free radical processes and the markers of endogenous intoxication at the conditions of effect on the rats organism by tetrachloride on the background of malathion.

Materials and methods. While carrying out an experiment white rats were intoxicated by carbon tetrachloride intoxication (4th, 7th days of the affection) in a period of thirty days malathion affection. Rats were taken out of the experiment by the thiopental anesthesia.

Results and discussion. The experimental data proved the malathion and carbontetrachloride toxic effect, which increases the conditions of their combined using.

Conclusions. It was established, that the maximum activation of free radical processes and deepening endogenous intoxication observed on the seventh day affection by carbontetrachloride in a period of thirty days malathion intoxication.

Author Biographies

L. A. Boiko, I. Horbachevsky Ternopil State Medical University

assistant of the Department of General chemistry

L. S. Fira, I. Horbachevsky Ternopil State Medical University

professor, head of the pharmacy department NNI PO I. Horbachevsky Ternopil State Medical University

N. I. Burmas, I. Horbachevsky Ternopil State Medical University

assistant of the Department of General chemistry

I. R. Bekus, I. Horbachevsky Ternopil State Medical University

assistant professor the department of the Department of General chemistry

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Published

2017-06-16

Issue

No. 3(50) (2017)

Section

Pharmacology and biochemistry

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