Analysis of blood serum biochemical parameters during the treatment with sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate

D. M. Danilchenko

Abstract


Topicality. The search of new biologically active compounds among 1,2,4-triazole furan substituted is subject of publications. Each researcher reasonably proves the usage prospects of this particular class of synthetic derivatives as potential pharmacologically active substances. Thus, today we can confidently assert the facts of very successful combination of presented heterocyclic systems to create an individual promising scientific field of synthetic research.

Aim. To present and to analyze the serum biochemical parameters of experimental rats on the background of introduction the sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate, to make certain conclusions for future pharmacological implementations of the compound.

Materials and methods. The material of the study was 1 % aqueous solution of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate. Laboratory animals - white rats weighing 130-150 g were used for the study.

Results and discussion. The use of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1 % aqueous solution leads to increase of alanine aminotransferase activity and partly to reduce of aspartate aminotransferase activity. Regarding to gamma glutamyl transpeptidase its level naturally decreases. There is a tendency to reduce the lactate dehydrogenase activity. Compared with the control group the use of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1% aqueous solution leads to increase of glucose level. It should be also noted the trend towards reduction of cholesterol level, significant decrease of triacylglyceride and concentration of uric acid. As for the second group of animals it is marked the tendency to increase the seromucoid level in blood serum. These parameters of blood serum as alkaline phosphatase, urea, α-amylase, bilirubin, inorganic phosphorus and calcium had no significant fluctuations after application of the solutions in the two test groups.

Conclusions. Analysis of biochemical studies may show a high probability of the use of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1 % aqueous solution in the future as a potential antioxidant and immune-modulating agent.


Keywords


serum biochemical parameters; alanine aminotransferase activity; seromucoid level; urea; immune-modulating agent; sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1 % aqueous solution

References


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DOI: https://doi.org/10.24959/ubphj.17.115

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)