Analysis of blood serum biochemical parameters during the treatment with sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate
Keywords:serum biochemical parameters, alanine aminotransferase activity, seromucoid level, urea, immune-modulating agent, sodium 2-(4-amino-5-(furan-2-yl)-1, 2, 4-triazole-3-ylthio)acetate 1 % aqueous solution
Topicality. The search of new biologically active compounds among 1,2,4-triazole furan substituted is subject of publications. Each researcher reasonably proves the usage prospects of this particular class of synthetic derivatives as potential pharmacologically active substances. Thus, today we can confidently assert the facts of very successful combination of presented heterocyclic systems to create an individual promising scientific field of synthetic research.
Aim. To present and to analyze the serum biochemical parameters of experimental rats on the background of introduction the sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate, to make certain conclusions for future pharmacological implementations of the compound.
Materials and methods. The material of the study was 1 % aqueous solution of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate. Laboratory animals - white rats weighing 130-150 g were used for the study.
Results and discussion. The use of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1 % aqueous solution leads to increase of alanine aminotransferase activity and partly to reduce of aspartate aminotransferase activity. Regarding to gamma glutamyl transpeptidase its level naturally decreases. There is a tendency to reduce the lactate dehydrogenase activity. Compared with the control group the use of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1% aqueous solution leads to increase of glucose level. It should be also noted the trend towards reduction of cholesterol level, significant decrease of triacylglyceride and concentration of uric acid. As for the second group of animals it is marked the tendency to increase the seromucoid level in blood serum. These parameters of blood serum as alkaline phosphatase, urea, α-amylase, bilirubin, inorganic phosphorus and calcium had no significant fluctuations after application of the solutions in the two test groups.
Conclusions. Analysis of biochemical studies may show a high probability of the use of sodium 2-(4-amino-5-(furan-2-yl)-1,2,4-triazole-3-ylthio)acetate 1 % aqueous solution in the future as a potential antioxidant and immune-modulating agent.
Bihdan, O. A., Parchenko, V. V., Panasenko, O. I., Knysh, Ye. H. (2016). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 3 (22), 98–102.
Hassan, F. A., Younus, Kh. W., AL–Qaisi, A. H. (2013). Antitumoral effect of 1,2,4–Triazole derivatives on prostate carcinoma (DU145), Human Liver carcinoma (HEPG2), and Human Breast Cancer (MCF7) cell Lines. Australian Journal of Basic and Applied Sciences, 7 (2), 133–140.
Basoglu, S., Yolal, M., Demirci, S., Demirbas, N., Bektas, H., Karaoglu, A. (2013). Design, synthesis and antimicrobial activities of some azole derivatives. Acta Poloniae Pharmaceutican Drug Research, 2 (70), 229–236.
Parchenko, V. V. (2015). Farmatsevtychnyi zhurnal, 6, 56–60.
Ovsepian, T. R., Grboian, S. V., Arsenian, F. G., Melik–Ogandzhanian, R. G. (2011). Khimiko–farmatcevticheskii zhurnal, 45 (12), 3–6.
Pruglo, Y. S., Pohorlyuk, A. Y., Parchenko, V. V., Panasenko, A. I., Knysh, E. G. (2016). Antiviral activity of trifuzol for the broiler at poultry farm. Zaporozhye Medical Journal, 0 (1). doi: 10.14739/2310–1210.2016.1.64062
Parchenko, V. V. (2015). Sbornik nauchnykh trudov S–World, 1 (38), 68–75.
Parchenko, V. V. (2014). Problemy vyiskovoi okhorony zdorovia, 41, 222–231.
Danilchenko, D. M., Zvenihorodska, T. V., Parchenko, V. V. (2017). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 1 (23), 76–80.
Copyright (c) 2017 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).