Comparative investigation of hydroxycitric acid and apples phenolic compounds food concentrate on parameters of nitric oxide system under experimental insulin resistance in rats
DOI:
https://doi.org/10.24959/ubphj.17.122Keywords:
apples phenolic compounds food concentrate, hydroxycitric acid, endothelial dysfunction, nitrogen oxide systemAbstract
Topicality. The insulin resistance syndrome development is usually correlated with endothelial dysfunction formation, which leads to cardiovascular complications. Accordingly, insulin resistance syndromes pharmacocorrectors should not contribute to endothelium functional state disturbances formation.
Aim. Therefore, the aim of present work was a comparative investigation efficacy of hydroxycitric acid and food concentrate phenolic compounds of apples for correction endothelium functional state disturbances under experimental insulin resistance in rats.
Materials and methods. The insulin resistance syndrome was modeled by prolonged intraperitoneal injection of dexamethasone and animal maintenance on a high-calorie diet. Serum glucose, immunoreactive insulin, total content of nitrates and nitrites, citrulline, arginine were determined and the insulin resistance index was calculated.
Results and discussion. The results demonstrate that hydroxycitric acid and apples phenolic compounds food concentrate corrects hyperglycemia and hyperinsulinemia, have a beneficial effect preventing endothelial dysfunction formation, which is primarily due to pronounced antioxidant properties.
Conclusions. In terms of effect on carbohydrate metabolism, a more pronounced effect was observed with hydroxycitric acid administration, and the effect on endothelium functional state parameters more pronounced effect was observed with the apples phenolic compounds food concentrate administration.
References
Eringa, E. C., Serne, E. H., Meijer, R. I., Schalkwijk, C. G., Houben, A. J. H. M., Stehouwer, C. D. A., van Hinsbergh, V. W. M. (2013). Endothelial dysfunction in (pre)diabetes: Characteristics, causative mechanisms and pathogenic role in type 2 diabetes. Reviews in Endocrine and Metabolic Disorders, 14 (1), 39–48. doi: 10.1007/s11154–013–9239–7
Mudau, M., Genis, A., Lochner, A., Strijdom, H. (2012). Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovascular Journal of Africa, 23 (4), 222–231. doi: 10.5830/cvja–2011–068
Zagaiko, A. L., Shkapo, A. I., Briukhanova, T. O. (2016). Ukrainskyi biofarmatsevtychnyi zhurnal – Ukrainian biopharmaceutical journal, 3, 75–79.
Zagaiko, A. L., Briukhanova, T. O. (2016). Ukrainskyi biofarmatsevtychnyi zhurnal – Ukrainian biopharmaceutical journal, 5, 37–42.
Zagaiko, A. L., Briukhanova, T. O., Shkapo, A. I. (2015). Modyfikatsiia metodu modeliuvannia eksperymentalnoi insulinorezystentnosti u shchuriv. Kyiv, 85–2015, 7.
Kolb, V., Kamyshnikov, V. (1982). Spravochnik po klinicheskoi khimii.Minsk, 366.
Kovaleva, O., Gorbach, T., Demydenko, G. (2009). Diagnostika endotelialnoi funktcii – otcenka vazoaktivnogo pula oksida azota. Kiev, 19.
Zagayko, A. L., Shkapo, A. I., Fylymonenko, V. P., Briukhanova, T. O. (2016). The impact of hydroxycitric acid on the lipid metabolism profile under experimental insulin resistance syndrome of syrian hamsters. The Ukrainian Biochemical Journal, 88 (3), 78–82. doi: 10.15407/ubj88.03.078
Bondonno, C. P., Yang, X., Croft, K. D., Considine, M. J., Ward, N. C., Rich, L., Hodgson, J. M. (2012). Flavonoid–rich apples and nitrate–rich spinach augment nitric oxide status and improve endothelial function in healthy men and women: a randomized controlled trial. Free Radical Biology and Medicine, 52 (1), 95–102. doi: 10.1016/j.freeradbiomed.2011.09.028
Jia, G., Sowers, J. R. (2014). Endothelial Dysfunction Potentially Interacts With Impaired Glucose Metabolism to Increase Cardiovascular Risk. Hypertension, 64 (6), 1192–1193. doi: 10.1161/hypertensionaha.114.04348
Davis, B. J., Xie, Z., Viollet, B., Zou, M.–H. (2006). Activation of the AMP–Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase. Diabetes, 55 (2), 496–505. doi: 10.2337/diabetes.55.02.06.db05–1064
Aguirre, L. (2011). Beneficial Effects of Quercetin on Obesity and Diabetes. The Open Nutraceuticals Journal, 4 (1), 189–198. doi: 10.2174/1876396001104010189
Jeong, S.–M., Kang, M.–J., Choi, H.–N., Kim, J.–H., Kim, J.–I. (2012). Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice. Nutrition Research and Practice, (3), 201. doi: 10.4162/nrp.2012.6.3.201
Li, J.–M., Wang, C., Hu, Q.–H., Kong, L.–D. (2008). Fructose Induced Leptin Dysfunction and Improvement by Quercetin and Rutin in Rats. Chinese Journal of Natural Medicines, 6 (6), 466–473. doi: 10.1016/s1875–5364(09)60038–8
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