Evaluation of medicines containing mometasone furoate or methylprednisolone aceponate with ceramides influence on the development of non-specific contact dermatitis
Keywords:glucocorticosteroids, non-specific dermatitis, proteins of the acute phase of inflammation
Topicality. High level of dermatitis diseases in the population of Ukrainian, increasing the number of severe clinical forms and low indicator of recovery make a problem of dermatitis therapy, which is the one of topical problems in dermatology.
Aim. the evaluation of medicines containing mometasone furoate or methylprednisolone aceponate with ceramides influence on the development of non-specific contact dermatitis. Medicines effect investigation were on the level of proteins of the inflammation acute phase and the antioxidant system state.
Materials and methods. Studies were conducted on a model non-specific contact dermatitis in rats. The effectiveness of the treatment was assessed by the intensity of skin lesions, by the level of proteins of the acute phase of inflammation (haptoglobin, CRP), and the state of the antioxidant system (AOS) – by the content of SH-groups.
Results and discusssion. It was found that application of crem mometasone with ceramides and ointment methylprednisolone with ceramides reduces skin lesions (on 67.3 % and 78.5 %, respectively) and promotes normalization of antioxidant system. Therapeutic effectiveness of the study medicines were consistent with the comparator drug.
Conclusions. The further pharmacological study of the proposed combinations with glucocorticosteroids and ceramides is promising in dermatology.
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