Aromatase inhibitors effect on the total protein content of visceral adipose tissue in hamsters with metabolic syndrome

A. L. Zagayko, D. V. Lytkin, K. V. Strelchenko

Abstract


Topicality. Recently, more attention has been paid to the role of the peripheral aromatase reaction enhancement in pathogenesis of obesity and metabolic syndrome. About 39 % of men and 40 % of women over 18 around the world are overweight (BMI > 25) and in almost all cases they have an imbalance of sex hormones, which is caused by increased aromatase activity of adipose tissue.

Aim. To study the effect of aromatase inhibitors on the parameters of total body weight, protein content in adipose tissue and their correlation in hamsters with experimental metabolic syndrome.

Materials and methods. Protein content in the visceral adipose tissue homogenate was detected by the Lowry method in the Hartree modification. Statistical processing of the results was carried out by variational statistics methods using nonparametric methods of analysis, the interrelations between the signs were determined by the Pearson linear correlation coefficient.

Results and discussion. The most effective drug from the group of aromatase inhibitors which reduced hypertrophic growth of adipose tissue in all animals both sexes and ages was letrozole. Anastrozole and exemestane showed less efficacy, and had a better effect on young animals.

Conclusions. The letrozole administration at a dose of 0.309 mg/kg resulted in a significant decrease in the average body weight by 24-35 % and a corresponding increase in protein content of visceral adipose tissue by 12-46 % with a high correlation coefficient.


Keywords


aromatase; inhibitors; metabolic syndrome; letrozole; anastrozole; exemestane

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DOI: https://doi.org/10.24959/ubphj.17.127

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)