Pathogenetic aspects of hypolipidemic drugs antimicrobial potential in metabolic syndrome therapy: a theoretical study

M. M. Velikaya, N. Yu. Sheveleva, I. Yu. Tishchenko

Abstract


Topicality. Metabolic syndrome (MS) is an extremely common medical and social problem. However, there is no modern understanding of the MS ethiopathogenetic mechanisms. Debates about MS discuss different versions of the development of this symptom complex, when each of the clusters can be primary in the pathogenesis of MS. Therefore, any metabolic processes disorders in the human body are always accompanied with and lead to a changes in quantitative and qualitative microbiocenoses composition, and vice versa, microbiota imbalance may induce the development of pathological states including MS.

Aim. To analyze the published data that concern antimicrobial potential of modern drugs with lipid-lowering properties used in complex therapy of MS.

Materials and methods. Lipid-lowering agents and their direct or indirect antimicrobial effect may cause the microbiota imbalance in the human body. While studying the data, we analyzed antimicrobial potential of modern drugs with lipid-lowering properties used in complex therapy of MS. We studied recent research in the field of microecology and the results of significant effect in normal microflora on metabolic processes.

Results and discussion. According to modern concepts, an important pathogenetic link in the obesity and MS development is the imbalance in normal intestinal microflora. At the same time, lipid-lowering agents can have a direct or indirect antimicrobial effect and, consequently, cause an imbalance of microbiota in the human body. Thereby, it is important for the therapy effectiveness to take into account the significant antimicrobial potential of drugs used in the correction of metabolic disorders.

Conclusions. The future complex antimicrobial properties study of drugs used in the correction of described pathological states has a good perspective.


Keywords


metabolic syndrome; antimicrobial activity; dyslipidemia

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References


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DOI: https://doi.org/10.24959/ubphj.17.128

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)