The dosage form of biological active complex from chikling vetch anti-inflammatory and analgetic effects investigation


  • V. A. Volkovoy National University of Pharmacy
  • N. M. Shakhvatova National University of Pharmacy
  • M. Ye. Bereznyakova National University of Pharmacy
  • G. P. Fomina National University of Pharmacy



anti-inflammatory, analgesic action, carragenin, fetal acid, medicinal form of BAS complex, with rows of sowing


Topicality. In recent years, interest in phytotherapy has grown significantly. In the pharmaceutical market, more and more drugs of plant origin are emerging. The search for biologically active compounds of plant origin is of scientific and practical interest because of the fact that these compounds have a wide spectrum of pharmacological action and low toxicity.
Aim. To investigate the anti-inflammatory and analgesic drugs action of the seedlings with the conventional name “Latiron”.
Materials and methods. Study of the anti-inflammatory effect of “Lariton” on the carragenin edema model on 40 white nonlinear mice and the analgesic activity on the model of acetic acid in 18 white nonlinear rats.
Results and discussion. The results of the experimental study showed that the antiarrhythmic agent of “Latiron” also exhibits a moderate anti-inflammatory effect on carragenin edema, and an analgesic effect on the model of acetic acid in a dose of 40 mg/kg of animal weight.
Conclusions. Thus, the study of the polyvalent action of the dosage form “Latiron” is promising and expedient in the treatment of arrhythmias.

Author Biographies

V. A. Volkovoy, National University of Pharmacy

d. med. s. professor of the Department of Pathological Physiology

N. M. Shakhvatova, National University of Pharmacy

postgraduate student of the Department of Pathological Physiology

M. Ye. Bereznyakova, National University of Pharmacy

d. med. s. professor of the Department of Clinical Laboratory Diagnostics

G. P. Fomina, National University of Pharmacy

cand. med. s. associate professor Department of Clinical Laboratory Diagnostics


Grodzinskyi, A. M. (1992). Likarski roslyny. Кyiv: URE, 544.

Kovalev, V. N., Shestko, I. E., Konkina, I. A. (1990). Sostoianie i perspectivy sozdaniia novykh gotovykh lekarstvennykh sredstv i fitokhimicheskikh

preparatov. Kharkov, 15.

Mora, S., Cook, N., Buring, J. E., Ridker, P. M., Lee, I.–M. (2007). Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating

Mechanisms. Circulation, 116 (19), 2110–2118. doi: 10.1161/circulationaha.107.729939

Weiss, R. F., Fintelmann, V. (2006). Herbal Medicine. Stuttgart. New–York: Thieme, 438.

Perianayagam, J. B., Sharma, S. K., Pillai, K. K. (2006). Anti–inflammatory activity of Trichodesma indicum root extract in experimental animals.

Journal of Ethnopharmacology, 104 (3), 410–414. doi: 10.1016/j.jep.2005.08.077

Perianayagam, J. B., Sharma, S. K., Joseph, A., Christina, A. J. M. (2004). Evaluation of anti–pyretic and analgesic activity of Emblica officinalis

Gaertn. Journal of Ethnopharmacology, 95 (1), 83–85. doi: 10.1016/j.jep.2004.06.020

Stefanov, О. V. (2001). Doklinichi doslidzhennia likarskykh zasobiv. Kyiv: Avitsena, 292– 307.

Andersen, Q. M., Markham, K. R. (2006). Flavonoids: Chemistry, Biochemistry and Applications. London: Press Taylor & Francis group, 1197.

Shim, J.–U., Oh, P.–S., Lim, K.–T. (2009). Anti–inflammatory activity of ethanol extract from Geranium sibiricum Linne. Journal of Ethnopharmacology,

(1), 90–95. doi: 10.1016/j.jep.2009.08.004

Randall, L. O., Selitto, J. J. (2007). A method for measurement of analgesic activity on inflamed tissue. Archives International, 111 (4), 409–419.

World Health Statistics 2012 (2012). Geneva : WHO, 176.

Truhacheva, N. V. (2012). Matematicheskaia statistica v mediko–biologicheskikh issledovaniiakh s primeneniem paketa statistika. Moscow: GEOTAR–Media, 379.





Pharmacology and biochemistry