Investigation of different substances catharic properties made from Prunus domestica
DOI:
https://doi.org/10.24959/ubphj.17.134Keywords:
Domestic plum, Prunus domestica, laxative effect, Pikolaks, mice, intestineAbstract
Topicality. Prunus domestica is widely spread in Ukraine. Its fruits contain a wide range of biologically active substances with high antibacterial, antioxidant, lipid-lowering and other activities, however, the mono-drug based on plum on the pharmaceutical market of Ukraine is absent.
Aim. The aim of our work is to study the laxative activity of dry and liquid extracts from prunus domestica fruits with the goal to design a drug with laxative effect.
Materials and methods. From the fruits of the plum, water and alcohol extracts were obtained. Dry extracts contained fibers and water-soluble polysaccharides (WSPS). The content of phenolic compounds, flavonoids, hydroxycinnamic acids, anthocyanins was determined. The ability to increase intestinal contractions was assessed by the rate of passage of contrast mass in the intestines of mice by the Sticknay J. S. method. “Pikolaks” (Pharmak OJSC, Kiev, Ukraine) was used as the reference preparation.
Results and discussion. In the work, it was found that all the extracts showed a mild laxative effect. The highest efficacy was found in dry extracts containing fibers and WSPS. The aqueous and alcohol extracts were less effective with respect to the “Pikolaks” comparison preparation.
Conclusions. All the extracts studied showed mild laxative activity, the most active was a dry extract, which contained fibers. The findings indicate the need for further research to create a new drug based on plum fruit.
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