Investigation of hypoglycemic properties of ginger extract on type 2 diabetes mellitus experimental model, caused by dexamethasone

Authors

  • N. M. Kononenko National University of Pharmacy, Ukraine http://orcid.org/0000-0002-3850-6942
  • V. V. Chikitkina National University of Pharmacy, Ukraine
  • M. V. Sorokina National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ubphj.17.135

Keywords:

ginger extract, type 2 diabetes, dexamethasone, glycemia, insulinemia

Abstract

Topicality. In pharmacotherapy of type 2 diabetes mellitus and metabolic syndrome, whose complex of disorders develops against the background of insulin resistance, medicinal plants are used as an important prophylactic and therapeutic additon, which causes the urgency of developing new domestic anti-diabetic herbal medicinal products.
Aim. To study the anti-hyperglycemic properties of the extract of ginger on the experimental model of type 2 diabetes induced by dexamethasone.
Materials and methods. Type 2 diabetes mellitus was reproduced by subcutaneous administration of dexamethasone at a dose of 0.125 mg/kg to rats for 13 days. Antihyperglycemic effect was assessed on day 14 for the concentration of glucose and insulin in the blood serum and the insulin resistance index.
Results and discussion. The results of the study showed that ginger extract in doses of 50 and 80 mg/kg had a pronounced antihyperglycemic effect, which, according to obtained results, is implemented due to its ability to improve the sensitivity of peripheral tissues to the action of insulin, and thus to reduce the manifestations of insulin resistance.
The use of the extract of ginger in a dose of 80 mg/kg revealed the most pronounced correction of the parameters of carbohydrate metabolism. The severity of the anti-hyperglycemic effect of the extract of ginger at a dose of 80 mg/kg is comparable to the effect of harvesting Arfazetine.
Conclusions. The obtained results justify the expediency of further studying the extract of ginger at a dose of 80 mg/kg as a promising antidiabetic agent.

Author Biographies

N. M. Kononenko, National University of Pharmacy

Doctor of Medical Sciences, professor, head of the Department of pathological physiology

V. V. Chikitkina, National University of Pharmacy

PhD of Biology, associate professor of pathological physiology

M. V. Sorokina, National University of Pharmacy

graduate student of the department of pathological physiology

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Published

2017-10-17

Issue

Section

Pharmacology and biochemistry