Comparative study of gels safety for intimate hygiene

L. S. Petrovskaya, A. L. Zagayko, L. V. Galuzinska


Topicality. As is well known, the main components of any foam-cleaning means are surfactants (surfactants, detergents), which provide directly needed cleaning action. However, when analyzing the assortment of foaming means for a qualitative composition, it was noted that, as the main detergents in such products, unfortunately, the most commonly used surfactant is anionic surfactant (sodium laureth sulfate, ammonium lauryl sulfate, etc.), which negatively affect the state, are most often used as the main detergents in such agents the mucous membrane and the skin, as a result, have an irritating effect.
Aim. To conduct a comparative analysis of the safety of gels for intimate hygiene of the “mass market” segment, which are presented in the Ukrainian market and the developed gel.
Materials and methods. For this experiment, as a means of comparison, a number of modern gels for intimate hygiene of various manufacturers were chosen. Acute toxicity of the test samples was studied by applying to the pre-cut portion of the skin the back of the rats, which was at least 10 % of the total surface area of the animal. The test samples were applied in a thin layer. The way of contact test samples with the body is selected according to the intended use of the drug in clinical practice. A study of the possible local irritant effect of the test samples of gels for intimate hygiene was performed using the conjunctive test.
Results and discussion. The conducted studies showed that all experimental samples of gels belong to the class of practically non-toxic substances (toxicity class V – LD50 > 2810 mg/kg). It was found that most of the gel samples tested do not cause a local irritant effect, except those containing sodium laureth sulfate (an anionic surfactant that is capable of exhibiting a certain irritating effect).
Conclusions. We carried out the comparative analysis of gels for intimate hygiene safety by industrial production, presented on the Ukrainian market in the mass market segment, as well as the developed gel at the Department of Commodity Science of the National University of Pharmacy. It was established that all studied samples were non-toxic and had almost no local irritant effect.


acute toxicity; local irritant effect; detergents; gel for intimate hygiene


Petrovska, L. S. (2016). Vìsnik farmacìï, 4 (88), 50–53.

Petrovska, L. S., Baranova, I. I., Bezvala, Yu. A. (2017). Upravlіnnia, ekonomіka ta zabezpechennia yakostі v farmatsii, 1 (49), 28–33.

Petrovskaia, L. S. Baranova, I. I., Lobova, I. A., Bespalaia, Yu. A. (2017). Retsept, 20 (1), 36–41.

Katcambasa, A. D., Lotti, T. M. (2008). Evropeiskoe rukovodstvo po lecheniiu dermatologicheskikh zabolevanii. Moscow: Medpress–inform, 736.

Zapadniuk, M. P., Zapadniuk, V. I., Zakhariia, E. A. (1983). Laboratornye zhivotnye. Ispolzovanie v eksperimente. Kiev: Vysshaia shkola, 382.

Kovalenko, V. M., Stefanov, O. V., Maksymov, Yu. M., Trakhtenberh, І. M. (2001). Doklіnіchnі doslіdzhennia lіkarskykh zasobіv. Kyiv, 74–97.

GOST Style Citations

1. Петровська, Л. С. Оцінка основних тенденцій розвитку ринку піномийних засобів в Україні / Л. С. Петровська // Вісник фармації. – 2016. –
№4 (88). – С. 50–53.

2. Петровська, Л. С. Дослідження особливостей поведінки споживачів при виборі засобів для інтимної гігієни / Л. С. Петровська, І. І. Баранова, Ю. О. Безпала // Управління, економіка та забезпечення якості в фармації. – 2017. – № 1 (49). – С. 28–33.

3. Маркетинговый анализ средств для интимной гигиены, представленных на рынке Украины / Л. С. Петровская, И. И. Баранова, И. А. Лобова, Ю. А. Беспалая // Рецепт. – 2017. – № 20 (1). – С. 36–41.

4. Европейское руководство по лечению дерматологических заболеваний / под ред. А. Д. Кацамбаса, Т. М. Лотти. – М. : МЕДпресс – информ,
2008. – 736 с.

5. Западнюк, М. П. Лабораторные животные. Использование в эксперименте / М. П. Западнюк, В. И. Западнюк, Е. А. Захария. – К. : Высш.
шк., 1983. – 382 с.

6. Експериментальне вивчення токсичної дії потенційних лікарських засобів / В. М. Коваленко, О. В. Стефанов, Ю. М. Максимов, І. М. Трахтенберг // Доклінічні дослідження лікарських засобів : метод. рек. / за ред. чл.–кор. НАМН України О. В. Стефанова. – К., 2001. – С. 74–97.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)