Comparative experimental study of nephroprotective properties of glucosamine derivatives in combination with quercetin
Keywords:glucosamine hydrochloride, N-acetylglucosamine, quercetin, nephroprotective properties
Topicality. Optimization in treatment of chronic kidney disease (CKD) is an important problem in modern medicine. In Ukraine there are about 500 thousands patients with CKD, most of whom can not receive specialized medical care. Therefore, the search for effective drugs with nephroprotective action is an actual task for modern experimental pharmacology.
Aim. Comparative study of nephroprotective properties of glucosamine derivatives in combination with quercetin in conditions of membranous nephropathy development in rats.
Materials and methods. The study was performed on the model of doxorubicin nephropathy in 119 rats. In animals, the level of proteinuria, the kidney mass coefficient, the glomerular filtration rate were determined and the overall index of nephroprotective activity was calculated.
Results and discussion. In the course of the study, it was shown that the combination of glucosamine derivatives with quercetin leads to a significant increase of the nephroprotective activity, which was most pronounced at the study of combinations with a ratio 3 : 1. The highest level of activity, 89.9 %, was shown by a combination containing glucosamine hydrochloride, N-acetylglucosamine and quercetin in a ratio 3 : 3 : 2.
Conclusions. Derivatives of glucosamine in combination with quercetin have a nephroprotective effect, which is most pronounced at the ratio of aminosugars and quercetin 3 : 1. It is advisable to further study of the nephroprotective properties of these combinations.
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