Comparative experimental study of nephroprotective properties of glucosamine derivatives in combination with quercetin
DOI:
https://doi.org/10.24959/ubphj.17.139Keywords:
glucosamine hydrochloride, N-acetylglucosamine, quercetin, nephroprotective propertiesAbstract
Topicality. Optimization in treatment of chronic kidney disease (CKD) is an important problem in modern medicine. In Ukraine there are about 500 thousands patients with CKD, most of whom can not receive specialized medical care. Therefore, the search for effective drugs with nephroprotective action is an actual task for modern experimental pharmacology.
Aim. Comparative study of nephroprotective properties of glucosamine derivatives in combination with quercetin in conditions of membranous nephropathy development in rats.
Materials and methods. The study was performed on the model of doxorubicin nephropathy in 119 rats. In animals, the level of proteinuria, the kidney mass coefficient, the glomerular filtration rate were determined and the overall index of nephroprotective activity was calculated.
Results and discussion. In the course of the study, it was shown that the combination of glucosamine derivatives with quercetin leads to a significant increase of the nephroprotective activity, which was most pronounced at the study of combinations with a ratio 3 : 1. The highest level of activity, 89.9 %, was shown by a combination containing glucosamine hydrochloride, N-acetylglucosamine and quercetin in a ratio 3 : 3 : 2.
Conclusions. Derivatives of glucosamine in combination with quercetin have a nephroprotective effect, which is most pronounced at the ratio of aminosugars and quercetin 3 : 1. It is advisable to further study of the nephroprotective properties of these combinations.
References
Pyrikh, L. A., Ivanov, D. D. (2014). Nefrolohiia. Donetsk: Vydavets Zaslavskyi, 292.
Kolesnyk, M. O., Saidakova, N. O., Kozliuk, N. I. et al. (2017). Ukrainskyi zhurnal nefrolohii ta dializu, 1 (53), 3–12.
Skvortcov, V. V., Tumarenko, A. V. (2017). Klinicheskaia nefrologiia. Sankt–Peterburg: SpetsLit, 199.
Shebeko, S. K., Zupanets, I. A. (2006). Klinichna farmatsiia, 10 (2), 31–35.
Kharchenko, D. S. (2009). The research of quercetin parenteral form influence on the course of experimental glomerulonephritis. Drug Information
Journal, 2 (43), 228–229.
Kozhemiakin, Yu. M., Khromov, O. S., Filonenko, M. A., Saifetdinova, H. A. (2002). Naukovo–praktychni rekomendatsii z utrymannia laboratornykh
tvaryn ta roboty z nymy. Kyiv: Derzhavnyi farmakolohichnyi tsentr MOZ Ukrainy, 155.
Guide for the care and use of laboratory animals, 8th edition. (2011). Washington : The National Academies Press, 246.
European convention for the protection of vertebrate animals used for experimental and other scientific purpose: Council of Europe (1986). Strasbourg,
Shtryhol, S. Yu., Lisovyi V. M., Zupanets I. A. et al. (2009). Metody eksperymentalnoho modeliuvannia urazhennia nyrok dlia farmakolohichnykh
doslidzhen. Kharkiv: NUPh, 48.
Dolgov, V. V., Menshikov, V. V. (2012). Klinicheskaia laboratornaia diagnostika. Moscow: GEOTAR–Media, 928.
Kamyshnikov, V. S. (2011). Metody klinicheskikh laboratornykh issledovanii, 4–izd. Moscow: MEDpress–inform, 752.
Truhacheva, N. V. (2012). Matematicheskaia statistika v mediko–biologicheskikh issledovaniiakh s primeneniem paketa Statistica. Moscow: GEOTAR–Media, 379.
Downloads
Published
Issue
Section
License
Copyright (c) 2017 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
