Acute toxicity determination of “Latiron” medicinal form




acute toxicity, tablets form of complex BAS from Latyrus sativus, aymalin, alapinine


Topicality. Medical plants since olden times attracted attention for researchers by curative properties of its bioactive substances. Searching and creation of medicinal preparations of plant origin is one of the major tasks of pharmaceutical science. From data of folk medicine sowing is different characteristics, and one of them – anti-arrhythmic. By the previous researches conducted on the department of physiology of NUPH perspective of the use of medicinal form “Latiron” was well-proven.
Aim. The aim of this research was experimental study of acute toxicity of the medicinal form “Latiron” in tablets.                                                              Materials and methods. The acute toxicity of the medicinal form “Latiron” in tablets had been studied in experimental on two types of laboratory animal: mice and rats at two ways of introduction: intragastric and intraperitoneal. Connections entered as water solutions.                                                        Results and discussion. The analysis of results testifies that the medium-lethal dose of preparation at intraperitoneal introduction for mice makes 3740 mg/kg, and for rats 2310 mg/kg, intragastric introduction to ”Latiron” mice in doses a from 4000 to 6000 mg/kg, a from 6000 to 11000 mg/kg of body weight allowed rats to set that LD50, for mice makes 4870 mg/kg, for rats 1948 mg/kg. Watching animals was conducted during 3-th days. At comparison of acute toxicity of “Latiron” and preparations of comparison of “Latiron” in 3.8 times less toxic than aymalin and in 4.6 times – of alapinine.                                      Conclusions. Summarizing the got results, it is possible to draw conclusion, that “Latiron” for K. K. Sidorov`s classification has been proven to belong to practically non-toxic substances. “Latiron” is less toxic than aymalin in 3.8 times, and alapinine in 4.6 times. The therapeutic index of ”Latiron”, which characterizes the therapeutic action range, is greater in 6.4 times that the one of aymalin in 9.4 times than the index of alapinine.

Author Biographies

V. Volkovoy, National University of Pharmacy

Doctor of Medical Sciences, professor of the Department of Pathological Physiology

N. Shakhvatova, National University of Pharmacy

postgraduate student of the Department of Pathological Physiology

R. Yeremenko, National University of Pharmacy

Doctor of Biological Sciences, head of the Department of Clinical Laboratory Diagnostics

N. Derkach, National University of Pharmacy

candidate of Biological Sciences, associate professor of the department of Pathological Physiology

L. Karabut, National University of Pharmacy

candidate of Medical Sciences, associate professor of the department of Clinical Laboratory Diagnostics


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Pharmacology and biochemistry