Choice of active substances concentrations in developed foam means

L. Petrovska, A. Zagayko, L. Galuzinska

Abstract


Topicality. Regardless of the place of application, the composition of any modern foam – washing means has classical scheme: conducting of primary detergents (anionic) and secondary (amphoteric and non-ionic). The necessary viscosity is achieved by the way of introduction the thickeners of various mechanisms of action. Stability and shelf life of the finish product depends on the selected preservatives. Correcting the pH value significantly influences the physical and chemical indicators. Active substances are chose taking into account the object of influence, thanks to which a given spectrum of pharmacological action is achieve (eg, anti-inflammatory and moisturizing actions).
Aim. To select and to establish optimal active substances concentrations for developed foam means.
Materials and methods. To establish the concentrations of selected active substances for the gel for intimate hygiene and shampoo for babies, we conducted the following studies: study of a possible local irritant effect, which was performed by “conjunctiva test”; anti-inflammatory properties determination was carried out on acute inflammation model caused by injection of histamine; moisturizing effect was established while examining the ability of the compositions to retain water in the skin.
Results and discussion. Based on the biological studies, we have justified the rational concentrations of active substances for the developing foam means namely: gel for intimate hygiene (alantoin – 0.5 %, α-bisabolol – 0.01 % D-panthenol – 0.7 %, hydroxylation – 0.2 %) and shampoo for babies (allantoin – 0.1 %; hydroxyethyl is 0.2 %).
Conclusions. Based on the biological studies we have substantiated active agents concentrations in developed foam basics: gel for intimate hygiene and shampoo for babies: namely a gel for intimate hygiene (alantoin, α-bisabolol, D-panthenol, hydroxyethyl urea) and shampoo for infants (alantoin, hydroxyethyl urea), which are incapable of show a locally irritating effect on the skin and mucous membranes. Thanks to the introduction of a complex of active substances, it provides sufficient moisturizing and anti-inflammatory activity.


Keywords


biological activity; foam means; detergents; pH value

References


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GOST Style Citations


1. Surfactant improves irrigant penetration into unoperated sinuses / J. W. Rohrer, G. R. Dion, P. S. Brenner et al. // Am. J. Rhinol. Allergy. – 2012. –
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DOI: https://doi.org/10.24959/ubphj.17.141

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