Choice of active substances concentrations in developed foam means




biological activity, foam means, detergents, pH value


Topicality. Regardless of the place of application, the composition of any modern foam – washing means has classical scheme: conducting of primary detergents (anionic) and secondary (amphoteric and non-ionic). The necessary viscosity is achieved by the way of introduction the thickeners of various mechanisms of action. Stability and shelf life of the finish product depends on the selected preservatives. Correcting the pH value significantly influences the physical and chemical indicators. Active substances are chose taking into account the object of influence, thanks to which a given spectrum of pharmacological action is achieve (eg, anti-inflammatory and moisturizing actions).
Aim. To select and to establish optimal active substances concentrations for developed foam means.
Materials and methods. To establish the concentrations of selected active substances for the gel for intimate hygiene and shampoo for babies, we conducted the following studies: study of a possible local irritant effect, which was performed by “conjunctiva test”; anti-inflammatory properties determination was carried out on acute inflammation model caused by injection of histamine; moisturizing effect was established while examining the ability of the compositions to retain water in the skin.
Results and discussion. Based on the biological studies, we have justified the rational concentrations of active substances for the developing foam means namely: gel for intimate hygiene (alantoin – 0.5 %, α-bisabolol – 0.01 % D-panthenol – 0.7 %, hydroxylation – 0.2 %) and shampoo for babies (allantoin – 0.1 %; hydroxyethyl is 0.2 %).
Conclusions. Based on the biological studies we have substantiated active agents concentrations in developed foam basics: gel for intimate hygiene and shampoo for babies: namely a gel for intimate hygiene (alantoin, α-bisabolol, D-panthenol, hydroxyethyl urea) and shampoo for infants (alantoin, hydroxyethyl urea), which are incapable of show a locally irritating effect on the skin and mucous membranes. Thanks to the introduction of a complex of active substances, it provides sufficient moisturizing and anti-inflammatory activity.

Author Biographies

L. Petrovska, National University of Pharmacy

Candidate of Pharmacy (Ph. D), associate professor, Department of Cosmetology and Aromology

A. Zagayko, National University of Pharmacy

Doctor of Biological Sciences, professor, head of Biological Chemistry Department

L. Galuzinska, National University of Pharmacy

Candidate of Pharmacy (Ph. D), associate professor, Department of Biological Chemistry


Rohrer, J. W., Dion, G. R., Brenner, P. S., Abadie, W. M., McMains, K. C., Thomas, R. F., Weitzel, E. K. (2012). Surfactant improves irrigant penetration

into unoperated sinuses. American Journal of Rhinology & Allergy, 26 (3), 197–200. doi: 10.2500/ajra.2012.26.3761

Zana, R., Xia, J. (2004). Gemini Surfactants: Synthesis, Interfacial and Solution–Phase Behavior, and Applicalions. New York: Marcel Dekker, 345.

Shueller, R., Romanowski, P. (2003). Multifunctional Cocmetic. Cambridge: Cambridge University Press, 248 p.

Stamatas, G. N., Nikolovski, J., Mack, M. C., Kollias, N. (2010). Infant skin physiology and development during the first years of life: a review of

recent findings based on in vivo studies. International Journal of Cosmetic Science, 33 (1), 17–24. doi: 10.1111/j.1468–2494.2010.00611.x

Hoath, S. B., Maibach, H. I. (2003). Neonatal Skin: Structure and Function, 2-nd. New York: Marcel Dekker, 392.

Katcambasa, A. D., Lotti, T. M. (2008). Evropeiskoe rukovodstvo po lecheniiu dermatologicheskikh zabolevanii. Moscow: Medpress – inform, 736.

Zapadniuk, M. P., Zapadniuk, V. I., Zakhariia, E. A. (1983). Laboratornye zhivotnye. Ispolzovanie v eksperimente. Kiev: Vysshaia shkola, 382.

Kovalenko, V. M., Stefanov, O. V., Maksymov, Yu. M., Trakhtenberh, І. M. (2001). Doklіnіchnі doslіdzhennia lіkarskykh zasobіv. Kyiv, 74–97.





Pharmacology and biochemistry