Justification of surface-active substances choice in composition of suppositories for treatment of prostate gland benign diseases
DOI:
https://doi.org/10.24959/ubphj.17.143Keywords:
benign diseases of prostate gland, rectal suppositories, PEO-base, surface-active substances, organoleptic, physico-chemical and technological properties, osmotic activityAbstract
Introduction. Prevention and treatment of benign prostatic diseases remain one of the pressing problems of modern medicine. Rectal suppositories are one of the main dosage forms used in urological practice. In order to provide the necessary organoleptic, physico-chemical, technological and osmotic properties, into their composition surfactants are introduced.
The aim of this work was to select the optimal surfactant and to substantiate its concentration in the suppositories with indole-3-carbinol and meloxicam.
Materials and methods. As the research objects have been selected: the carrier – PEO-base, emulsifiers – Montanox 80, Lanette SX, Cremophor RH-40, Myverol 18-04K NF, soy lecithin. The investigation of organoleptic (appearance, absence of inclusions and stratifications, homogeneity at the cut), physico-chemical (pH, time of decomposition), technological (resistance to destruction) and osmotic (dialysis through a semipermeable membrane) properties of the suppositories by the methods of SPU has been performed.
Results and discussion. Model specimens of suppositories with Montanox 80, Lanette SX and soy lecithin comply with the requirements of the SPU for all quality indices. In order to reduce the osmotic activity of the developed suppositories, the addition of Montanox 80 emulsifier in the amount of 3 % was found to be most appropriate, which would not result in dehydration and overdrying of the rectum mucosa.
Conclusions. Experimental researches have established that the optimal surfactant in the composition of the suppositories with indole-3-carbinol and meloxicam, which provides the necessary qualitative characteristics and reduces the hyperosmotic properties of the polyethylene oxide base, is Montanox 80 in the amount of 3 %.
References
Aliaev, Yu. G. (2009). Bolezni predstatelnoi zhelezy, 240.
Haverkamp, J., Charbonneau, B., Ratliff, T. L. (2008). Prostate inflammation and its potential impact on prostate cancer: A current review. Journal
of Cellular Biochemistry, 103 (5), 1344–1353. doi: 10.1002/jcb.21536
Filippovich, V. A. (2008). Zhurnal Grodnenskogo gosudarstvennogo meditcinskogo universiteta, 1, 93–101.
Pankrusheva, T. A., Erofeeva, L. N., Orlova, T. V., Kurilova, O. O., Chekmareva, M. S. (2016). Kurskii nauchno–prakticheskii vestnik “Chelovek i ego zdorove”, 2, 108–112.
Dziuba, A. S., Trofimova, E. O. (2014). Farmatciia, 3, 27–30.
Orlova, T. V. (2014). Vestnik Voronezhskogo gosudarstvennogo universisteta. Seriia : Khimiia. Biologiia. Farmatciia, 1, 126–133.
Zaichenko, V. S., Ruban, O. A., Maslii, Ju. S., Gerbina, N. A. (2017). Justification for the Composition and Method of Active Pharmaceutical Ingredients Administration
at the Development of Suppositories for the Treatment of Benign Prostate Gland Diseases. Asian Journal of Pharmaceutics, 11 (2), 129–134.
Bykovskii, S. N. et al. (2015). Farmatcevticheskaia razrabotka. Moscow: Pero, 472.
Abramovich, R. A., Vorobev, A. N., Elagina, I. A., Sinitcyna, N. I. (2012). Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriia:
Meditcina. Farmatciia, 18, 10–3 (129), 101–104.
Zorro, M. Dal, Franceschinis, E., Punchina, A., Realdon, N. (2012). Effect of the surfactant on the availability of piroxicam as a poorly hydrosoluble
drug from suppositories. Pharmazie, 1, 37–45.
Orlova, T. V., Pankrusheva, T. A. (2013). Vspomogatelnye veshchestva v tekhnologii suppozitoriev i nauchno–metodicheskie podkhody k ikh vyboru, 160.
Derzhavna Farmakopeia Ukrainy : v 3 t. (2015). Kyiv: Ukrayinskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv, 1, 1128.
Touitou, E., Donbrow, M., Azaz, E. (2005). New hydrophilic vehicles enabling rectal and vaginal absorbtion. Drug Delivery, 1, 399–407.
Romanina, D. M., Gladyshev, V. V., Lisianskaia, A. P., Kechin, I. L. (2016). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 3 (22), 23–27.
Orlova, T. V., Pankrusheva, T. A. (2014). Farmatciia, 1, 34–38.
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