Study of the hyaluronic acid solubility for development of the vaginal gel composition
DOI:
https://doi.org/10.24959/ubphj.17.147Keywords:
hyaluronic acid, vaginal gel, solubilityAbstract
Topicality. Hyaluronic acid is widely used in cosmetic and medical products as a moisturizing, anti-inflammatory and reparative component. Currently, the urgent issue is the expansion of the assortment of medicines of native production, which include hyaluronic acid.
Aim. The research is devoted to the choice of the optimal solvent for the insertion of hyaluronic acid into a composition of vaginal gel.
Materials and methods. The object of the study was low molecular weight hyaluronic acid with a molecular weight of 0.09 × 10^6 Da. Microscopic analysis using a Microscope Konus Academi has been carried out to study the dissolution of the hyaluronic acid powder in water, peach oil, the most common hydrophilic non-aqueous solvents and mixtures thereof.
Results and discussion. In the course of the study, the shape and size of the hyaluronic acid particles in various solvents and their mixtures were determined.
Conclusions. It has been established that the hyaluronic acid is unlimitedly swells in water at a temperature of 20 °C. Addition of PEO-400 and propylene glycol improves its wetting and distribution of particles in solvent volume. The addition of tween-80 to purified water has allowed increasing the speed and completeness of the hyaluronic acid dissolution.
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