Study of the influence of extract from the leaves of Corylus avellana on coagulation hemostasis

Authors

DOI:

https://doi.org/10.24959/ubphj.17.95

Keywords:

extract from the leaves of Corylus avellana, thrombophlebitis, anticoagulant activity

Abstract

Topicality. In consequence, insufficiently studied of the pharmacological actions of Corylus avellana, folk medicine makes it more important significance than scientific. in this connection pharmacological study of Corylus avellana is
reasonable in terms of expanding field of application of this herb, including the study of its anticoagulant action.
Aim. To study the effect of the extract from the leaves of Corylus avellana on the coagulation hemostasis in experimental model of thrombophlebitis of peripheral veins in rabbits.
Materials and methods. The object of the study was a thick extract from the leaves of Corylus avellana. The study of the anticoagulant effect of the extract was carried out on the model of experimental thrombosis of peripheral veins in
rabbits using screening tests for the assessment of coagulation hemostasis.
Results and discussion. It has been established that the investigated extract affects the intrernal pathway formation of prothrombinase and the final stage of blood clotting – fibrin formation. Prolongation of APTT has indicates a
direct anticoagulant effect of the extract from the leaves of Corylus avellana, expression that action prevails comparison drug eskuvit.
Conclusions. The obtained results allow to recommend the extract from the leaves of Corylus avellana as a therapeutic and preventive remedy in order to prevent the spread of thrombosis with thrombophlebitis and thrombosis.

Author Biographies

A. S. Kalenichenko, National University of Pharmacy

Postgraduate student of the human physiology and anatomy department

L. N. Maloshtan, National University of Pharmacy

D. biol. s., professor, head of the human physiology and anatomy department

Yu. A. Fedchenkova, National University of Pharmacy

C. pharm. s, associate professor of the Pharmacognosy department

References

Определитель высших растений Украины / под ред. Д. Н. Доброчаева, Н. И. Котова, Ю. Н. Прокудина и др. – К. : Наук. думка, 1987. – С. 548.

Хворост, О. П. Фармакогностичне вивчення рослин порядку березоцвіті та отримання нових біологічно активних субстанцій різної

спрямованості дії: автореф. дис. … докт. фарм. наук: спец. 15.00.02 «Фармацевтична хімія та фармакогнозія» / Хворост Ольга Павлівна;

Національний фармацевтичний університет. – Х., 2006. – 34 с.

Мовсумов, И. С. Биологически активные вещества Corylus avellana L., произрастающей в Азербайджане / И. С. Мовсумов, Д. Ю. Юсифова,

Э. А. Гараев // Химия растительного сырья. – 2013. – № 4. – С. 259–261.

Hazel (Corylus avellana L.) leaves as source of antimicrobial and antioxidative compounds / I. Oliveira, A. Sousa, P. Valentaet et al. // Food

Chemistry. – 2007. – № 105. – P. 1018–1025.

Духанин, А. С. Актуальные вопросы применения ангиопротекторов / А. С. Духанин, Л. Н. Шимановский // Междунар. мед. журн. – 2015. –

№ 2. – С. 79–85.

Спосіб моделювання тромбофлебітів периферичних судин: Інформаційний лист, протокол № 25 від 20.11.2002 р., Національний фар-

мацевтичний університет МОЗ України / уклад. : Л. М. Малоштан, О. В. Должикова, І. О. Батура. – К. : Укрмедпатентпром, 2002. – 2 с.

Бокарев, И. Н. Лабораторные методы исследования системы свертывания крови : метод. рек. / И. Н. Бокарев. – 2–е изд. – М. : АТГПСС им.

А. Шмидта – Б. А. Кудряшова, 2011. – 15 с.

Медведев, В. В. Клиническая лабораторная диагностика: справочник для врачей / В. В. Медведев, Ю. З. Волчек ; под ред. В. А. Яковлева. –

СПб. : Гиппократ, 2006. – 360 с.

Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / под общ. ред. чл.-кор. РАМН,

профессора Р. У. Хабриева. – 2–изд. перераб. и доп. – М. : Медицина, 2005. – 832 с.

Downloads

Published

2017-02-17

Issue

No. 1(48) (2017)

Section

Pharmacology and biochemistry

License

Copyright (c) 2017 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).