Influence of the ointment “Allergolik”, which containes the dry extract of licorice rhizome, to the morphological state of guinea pigs’ skin with allergic contact dermatitis

Authors

DOI:

https://doi.org/10.24959/ubphj.17.96

Keywords:

licorice root extract, morphological state of skin, allergic contact dermatitis

Abstract

Topicality. Herbal medicinal products are perspective for external application of the inflammatory skin diseases, which have complex pharmacological effect, can be used continuously without significant side effects, characterized low
cost and ease manufacture.
Aim. To investigate the influence of ointment “Allergolik”, which contains the dry extract of licorice rhizome, to the morphological state of guinea pigs’ skin with allergic contact dermatitis (ACD).
Materials and Methods. Modeling of ACD was performed by the method Zalkan P. M., Iyevleva E. A., as allergen 2,4-dinitrochlorobenzene was used. The ointment “Allergolik” was developed at the Department of Drug Technology the
National University of Pharmacy. Ointment “Fladeks” was used as a reference drug.
Results and Discussion. Obtained morphological data showed that cutaneous application of 2,4-dinitrochlorobenzene leads to the development of the morphological picture of the ACD. The treatment with ointment “Allergolik” has
prevented the ACD development – changes in the skin of animals were moderate and residual. Ointment “Fladeks” showed light positive effect on the skin morphology of guinea pigs with model pathology.
Conclusions. Based on our study of the morphological state of guinea pigs’ skin with ACD it was shown that the ointment “Allergolik” has a pronounced anti-allergenic and anti-inflammatory effects and the efficiency more than the
reference drug “Fladeks”. Therefore, further studying of the ointment “Allergolik” for the purpose of their use in the therapy of allegro dermatitis is perspective.

Author Biographies

L. N. Maloshtan, National University of Pharmacy

d. biol. s., professor, head of the Human Anatomy and Physiology Department

E. A. Zeghdani, National University of Pharmacy

postgraduate student of the Human Anatomy and Physiology Department

L. A. Shakina, National University of Pharmacy

c. biol. s, professor assistant of the Human Anatomy and Physiology Department

Yu. B. Laryanovska, National University of Pharmacy

c. biol. s, senior research scientist

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Published

2017-02-17

Issue

No. 1(48) (2017)

Section

Pharmacology and biochemistry

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