Antioxidant and frigoprotective properties of glucosamine preparations and acetylsalicylic acid under conditions of acute local cold trauma
DOI:
https://doi.org/10.24959/ubphj.18.153Keywords:
glucosamine hydrochloride, acetylsalicylic acid, cold trauma, hypothermia, lipid peroxidation, antioxidant systemAbstract
Topicality. Cold trauma (HT) is a common factor of the environmental impact on human body. They are found in all parts of our planet and in the structure of peacetime trauma are from 3 to 10 %, accompanied by significant disability of victims and mortality. Acute exposure to cold leads to increasing of free radicals formation, contributes to antioxidant system depletion (AOS) and activates lipid peroxidation (LPO).
Aim. To study the effect of glucosamine and acetylsalicylic acid (ASA) preparations on the course of experimental pathology (the state of the affected area of the skin, body temperature, body mass dynamics), the intensity of LPO and the state of AOS under conditions of model acute local CT (frostbite).
Materials and methods. As the frigoprotectors are selected G h/ch (Sigma-Aldrich, USA), “Glucosamine-S BHFZ” and the drug ASK (“Darnitsa”, Kiev). After a local CT, the rectal temperature, skin lesions, LPO and AOS in the blood serum were measured.
Results and discussion. G h/ch exhibits a more pronounced frigoprotective effect with local acute CT in terms of: skin lesions, restoration of rectal temperature and body weight, antioxidant effect, superior to ASA and Glucosamine-C BHPF.
Conclusions. The antioxidant properties of G h/ch, “Glucosamine-C BHFZ” and to a lesser extent ASA, which were detected in acute general cooling, are confirmed in this work under local CT conditions. These results substantiate the expediency of using these agents, primarily glucosamine, in the treatment of local cold trauma.
References
Andreev, O. V., Fistal, N. N., Gioduretc, D. P. (2005). Vestnik neotlozhnoi i vosstanovitelnoi meditciny, 6 (2), 247–249.
Dmitriev, A. (2012). Grazhdanskaia zashchita, 3, 56–58.
Oliinyk, H. A. (2013). Meditcina neotlozhnykh sostoianii, 8 (55).
Afanaseva, R. F., Burmistrova, O. V. (2006). Bezopasnost zhyznedeiatelnosti, 2, 16–20.
Golokhvast, K. S., Chaika, V. V. (2011). Vestnik novykh meditcinskikh tekhnologii, 18 (2), 486–489.
Menshykova, E. B., Zenkov, N. K. (1993). Okislitelnyi stress (diagnostika, terapiia, profilaktika). Novosibirsk: Nauka, 181.
Podkolzin, A. A., Megreladze, A. G., Dontcov, V. I. et al. (2000). Profilaktika stareniia, 3, 18–36.
Bondariev, Ye. V., Shtryhol, S. Yu. (2010). Klinichna farmatsiia – Clinical Pharmacy, 14 (4), 47–49.
Korshunova, N. V., Dorovskikh, V. A. (1999). Sposob korrektcii organizma krys k kholodovomu vozdeistviiu. Patent 2131735, Amurskaia gosudarstvennaia
meditcynskaia akademiia, A61K 35/32, A23K1/00; declared 02.07.1996; published 20.06.1999.
Bondariev, Ye. V., Shtryhol, S. Yu., Piminov, O. F., Domar, N. A. (2009). Zastosuvannia hliukozaminu hidrokhlorydu yak zasobu fryhoprotektornoi dii.
Patent 52370, Ukraina, A61K 31/726, A61R 43/00; declared 19.02.2010; published 25.08.2010, №16.
Bondarev, E. V., Shtrygol, S. Yu. (2016). Vestnik farmatcii – News of Pharmacy, 3 (73), 92–97.
Bondarev, E. V., Shtrygol, S. Yu. (2017). Respublikanskii nauchnyi zhurnal «Vestnik», 2 (79), 30–36.
Khabriev, R. U. (2005). Rukovodstvo po eksperimentalnomu (doklinicheskomu) izucheniiu novykh farmakologicheskikh veshchestv. Moscow: Meditcina, 832.
Boiko, V. V., Milovidova, A. E., Yanovskaia L. G. (2010). Vistnyk morfolohii, 16 (3), 526–529.
Koroliuk, M. A., Ivanova, L. I., Maiorova, I. G. et al. (1988). Laboratornoe delo, 1, 16–19.
Orekhovich, V. N. (1977). Sovremennye metody v biokhimii. Moscow: Meditcina, 62–68.
Stalnaia, I. D. (1977). Sovremennye metody v biokhimii, 63–64.
Lapach, S. N., Chubenko, A. V., Babich, P. N. (2000). Statisticheskie metody v mediko–biologicheskikh issledovaniiakh s ispolzovaniem Excel. Kiev:
Morion, 320.
Sizonenko, V. A., Mikhailichenko, A. V., Shapovalov, K. G. (2008). Biul. SO RAMN, 3, 134–135.
Nikolaev, V. M. (2007). Izmeneniia prooksidantno–antioksidantnogo ravnovesiia v otvetnykh ekologo–biokhimicheskikh reaktciiakh organizma zhivotnykh i cheloveka na deistvie kholoda. Yakutsk, 188.
Bondariev, Ye. V., Shtryhol, S. Yu., Zupanets, I. A., Otrishko, I. A. (2017). Klinichna farmatsiia – Clinical Pharmacy, 21 (1), 50– 56.
Nazarenko, N. A. (2001). Effektivnost nesteroidnykh protivovospalitelnykh sredstv dlia profilaktiki i lecheniia kholodovoi travmy. Arkhanhelsk, 38.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
