Substantiation of the film-forming agent selection in the composition of spray with copper and silver citrate
Keywords:veterinary drug, antiseptic spray, film-forming agent, copper and silver citrate
Topicality. Mastitis continues to be the most common disease of dairy cows. In order to prevent the infection of the mammary gland in cows, the udders were treated with a suitable disinfectant, by spraying or full immersion in the
Aim of this work the choice of a film-forming agent in the composition of copper and silver citrates containing spray and the effect of the film-forming agent on the quality parameters of the antiseptic agent.
Materials and methods. As the research objects have been selected: film-forming agent: sodium carboxymethyl cellulose (CMC), macrogol-400, polyquaternium 10. The quantitative content of silver ions in the spray was determined thiocyanometric measurement. The quantitative content of copper ions, dexpanthenol; potentiometric determination of pH and statistical analysis of the results was carried out in accordance with the requirements of the S.Ph.U.
Results and discussion. Samples of CMC-containing spray 0.3 %, 0.5 % and 1 % were sticky and formed a thick film which did not meet the requirements of normative and technical document (NTD) in terms of “Relative density”. The conducted studies allowed us to conclude that it is inappropriate to introduce macrogol-400 as a film-forming agent in an amount from 10 % to 20 % into the composition of the combined spray for the veterinary use. Spray obtained with its use form very thin film, and when applied to the skin is washed out quickly. In addition, the samples do not meet the requirements of the NTD.
Conclusions. It has been established that the optimum film-forming agent in composition of antiseptic spray is polyquaternium 10 in the amount of 0.5 %, which allowed to obtain a film with predictable properties, and the preparation itself meets the requirements of the design developed by the normative and technical documentation for all indicators of quality.
Hiitiö, H., Vakkamäki, J., Simojoki, H., Autio, T., Junnila, J., Pelkonen, S., Pyörälä, S. (2017). Prevalence of subclinical mastitis in Finnish dairy cows:
changes during recent decades and impact of cow and herd factors. Acta Veterinaria Scandinavica, 59 (1). doi: 10.1186/s13028–017–0288–x
Oosterom, J. (1991). Epidemiological studies and proposed preventive measures in the fight against human salmonellosis. International Journal
of Food Microbiology, 12 (1), 41–51. doi: 10.1016/0168–1605(91)90046–r
Limin, B. V., Burykina, I. M. (2009). Molochnaia promyshlennost, 4, 80–81.
Gibson, H., Sinclair, L. A., Brizuela, C. M., Worton, H. L., Protheroe, R. G. (2008). Effectiveness of selected premilking teat–cleaning regimes in reducing
teat microbial load on commercial dairy farms. Letters in Applied Microbiology, 46 (3), 295–300. doi: 10.1111/j.1472–765x.2007.02308.x
Garvey, M., Curran, D., Savage, M. (2016). Efficacy testing of teat dip solutions used as disinfectants for the dairy industry: Antimicrobial properties.
International Journal of Dairy Technology, 70 (2), 179–187. doi: 10.1111/1471–0307.12344
Mason, S. E., Mullen, K. A. E., Anderson, K. L., Washburn, S. P., Yeatts, J. L., Baynes, R. E. (2017). Pharmacokinetic analysis of thymol, carvacrol and
diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle. Food Additives & Contaminants: Part A, 1–10. doi: 10.1080/19440049.2017.1285056
Martins, C. M. M. R., Pinheiro, E. S. C., Gentilini, M., Benavides, M. L., Santos, M. V. (2017). Efficacy of a high free iodine barrier teat disinfectant for the prevention of naturally occurring new intramammary infections and clinical mastitis in dairy cows. Journal of Dairy Science, 100 (5), 3930–3939. doi: 10.3168/jds.2016–11193
French, E. A., Mukai, M., Zurakowski, M., Rauch, B., Gioia, G., Hillebrandt, J. R., Hemling, T. C. (2016). Iodide Residues in Milk Vary between Iodine– Based Teat Disinfectants. Journal of Food Science, 81 (7), T1864–T1870. doi: 10.1111/1750–3841.13358
Obrabotka vymeni pered doeniem. Available at: http://www.milkindustry.ru/products/43/
Sait kompanii DeLaval. Available at: https://www.delaval.com/en–us/our–solutions/milking/udder–health–hygiene/teat–dips/
Polova, Z. M., Nazarkina, V. M. (2017). The analysis of economic availability of veterinary preparations in the segment of anti–mastitis medicines.
Socìal’na Farmacìâ v Ohoronì Zdorov’â, 3 (3), 35–41. doi: 10.24959/sphhcj.17.86
Nazarkina, V. M., Polova, Zh. M. (2017). Analysis of modern approaches to formation of cost price for veterinary preparations. Vìsnik Farmacìï, 3 (91), 39–44. doi: 10.24959/nphj.17.2174
Polova, Zh. (2016). Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 1 (20), 71–74.
Polova, Zh. M. (2016). Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P. L. Shupyka, 25 (1), 563–568.
Polova, Zh. N., Sokolova, L. V. (2015). Respublikanskii nauchnyi zhurnal «VESTNIK» Yuzhno–Kazahkstanskoi gosudarstvennoi farmatcevticheskoi
akademii, 2 (71), 6–9.
Derzhavna Farmakopeia Ukrainy, v 3–kh tomakh (2nd ed.). (2015). Kharkiv: Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv, 1, 1128.
Commission Directive 91/412/EEC of 23 July 1991 laying down the principles and guidelines of good manufacturing practice for veterinary medicinal products. (1991). Official Journal of the European Communities L 228. Brussels, 70–73.
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