Study of antioxidant properties of dermatocosmetic remedies with plant substances using Paramecium caudatum biological model




alopecia, dermatocosmetic remedies, antioxidant effect, toxicity, Paramecium caudatum


Topicality. A promising direction in conducting preclinical drug research is the application of the biological model of Paramecium caudatum.

Aim. To study antioxidant properties and possible toxic effects of dermatocosmetic remedies (DKR) with plant substances applying the model of Paramecium caudatum.

Materials and methods. In order to study the antioxidant action of developed DKR it was evaluated their influence on the activity duration of Paramecium caudatum in the medium with toxic substances (1 % solution of hydrogen peroxide, 14 % ethanol). Potential toxicity was examined in the chronic trials considering growth and reproductive reactions and functional status of paramecia in the nutrient medium with the DKR added.

Results and discussion. It was determined that investigated DKR in comparison with control samples (1 % solution of hydrogen peroxide and 14 % ethanol) substantially prolonged the Paramecium caudatum activity period in the presence of cellular toxins. The results of chronic study showed that under the DKR influence the movement activity and cell multiplication frequency of Paramecia were significantly increased since in 3 days research , their numbers exceeded the control by 3-4 times.

Conclusions. The obtained results of the antioxidant activity and toxicity in the acute and chronic trials using Parameñium caudatum biological model confirm that at cellular level the developed DKR cause antioxidant (protective) effect and are non-toxic to the bioorganic system.

Author Biographies

M. I. Fedorovska, Ivano-Frankivsk National Medical University

candidate of Pharmaceutical Sciences, associate professor of the Organization and Economics in Pharmacy and Drug Technology Department

N. P. Polovko, National University of Pharmacy

doctor of Pharmaceutical Science, professor, head of the Pharmaceutical Technology of Drugs Department

O. P. Strilets, National University of Pharmacy

doctor of Pharmaceutical Science, professor of the Biotechnology Department


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Biopharmaceutical research