Improvement of careesprophylaxic gel composition

Authors

DOI:

https://doi.org/10.24959/ubphj.18.166

Keywords:

caries preventive gel, ocenidine-hexafluorosilicate, microbiological research

Abstract

Topicality. Prevention of caries involves a complex of actions aimed to prevent the disease of the century and strengthen the body’s protective forces. An effective method of protecting teeth – mineralization and fluoridation of enamel. Pharmacological studies have shown high effectiveness of oniyus hexafluorosilicates for caries prophylaxis.

Aim. To study antimicrobial activity of experimental samples for improvement of the composition of gel that have caries prophylactic action with octenidin-hexafluorosilicate (O-GFS).

Materials and methods. O-GFS gels were used as the object of the study. The antimicrobial activity of the gels was studied in vitro by the method of diffusion into agar (the method of “wells”). To visualize the homogeneity of gels, a biomagnetic microscope “Lumam-P1” was used.

Results and discussion. Microbiological studies have established the presence of a wide range of antimicrobial action of experimental samples, the intensity of which increases with the addition of essential oils. Insertion of essential oils causes a necessity of addition of co-solvents or solubilizers. Microscopic studies have shown the necessity of using PEG-400 GRO, which provides dissolution of essential oils at concentrations of 0.5 and 0.75 %, or polysorbate-80 at a concentration of 1 %,.

Conclusions. Octahedin-hexafluorosilicate gels have a wide spectrum of antimicrobial action, which increases with the insertion of essential oils. The use of solubilizers helps to dissolve essential oils and obtain homogeneous gels.

Author Biographies

V. Yu. Anisimov, Odessa National Medical University

candidate of Biological Sciences, associate professor of the Department of Pharmaceutical Chemistry, dean of Pharmaceutical faculty

V. O. Gelmboldt, Odessa National Medical University

Doctor of Chemistry, professor of the Department of Pharmaceutical Chemistry

N. P. Polovko, National University of Pharmacy

Doctor of Pharmaceutical Science, professor, head of the Pharmaceutical Technology of Drugs Department

O. P. Strilets, National University of Pharmacy

Doctor of Pharmaceutical Science, professor of Biotechnology Department

References

Anisimov, V. Yu., Gelmboldt, V. О., Polovko, N. P., Levytskyi, А. P. (2016). Likarskyi zasib u formi helu dlia profilaktyky stomatolohichnykh zakhvoriuvan. Ukraine Patent № 112620 МPК А 61 К 6/00, А 61 К 9/00, А 61 К 31/44, А 61 К 33/16. № a 2015 12112; declared 07.12.2015; published. 26.09.2016, № 18.

Gelmboldt, V. O., Anisimov, V. Yu., Shyshkin, I.O. (2017). Synthesis of octenidine hexafluorosilicate as new potential caries preventive and antibacterial agent. Pharmacentical review, 3, 13–16.

Lepsky, V. V., Anisimov, V. Yu., Lepsky, V. V. (2015). Biochemical mechanisms of the caries prophylaxis action of hexafluorosilicates. Journal of Education, Health and Sport, 5 (11), 289–299.

Volianskyi, Yu. L., Hrytsenko, I.S., Shyrobokov, V. P. et al. (2004). Vyvchennia spetsyfichnoi actyvnosti protymicrobnykh likarskykh zasobiv. Kyiv, 38.

Derzhavna Pharmakopeia Ukrainy (2nd ed.). (2015). Kharkiv: Ukrainskyi naukovyi farmacopeinyi tsentr yakosti likarskykh zasobiv, 1128.

Pertsev, І. М., Dmytrievskyi, D. І., Rybachuk, V. D. et al. (2010). Dopomizhni rechovyny v tekhnolohii likiv: vplyv na tekhnologichni, spozhyvchi, ekonomichni kharakterystyky i terapevtychnu efektyvnist. Kharkiv: Zoloti storinky, 600.

Downloads

Published

2018-06-12

Issue

No. 2(55) (2018)

Section

Biopharmaceutical research

License

Copyright (c) 2018 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).