Improvement of careesprophylaxic gel composition




caries preventive gel, ocenidine-hexafluorosilicate, microbiological research


Topicality. Prevention of caries involves a complex of actions aimed to prevent the disease of the century and strengthen the body’s protective forces. An effective method of protecting teeth – mineralization and fluoridation of enamel. Pharmacological studies have shown high effectiveness of oniyus hexafluorosilicates for caries prophylaxis.

Aim. To study antimicrobial activity of experimental samples for improvement of the composition of gel that have caries prophylactic action with octenidin-hexafluorosilicate (O-GFS).

Materials and methods. O-GFS gels were used as the object of the study. The antimicrobial activity of the gels was studied in vitro by the method of diffusion into agar (the method of “wells”). To visualize the homogeneity of gels, a biomagnetic microscope “Lumam-P1” was used.

Results and discussion. Microbiological studies have established the presence of a wide range of antimicrobial action of experimental samples, the intensity of which increases with the addition of essential oils. Insertion of essential oils causes a necessity of addition of co-solvents or solubilizers. Microscopic studies have shown the necessity of using PEG-400 GRO, which provides dissolution of essential oils at concentrations of 0.5 and 0.75 %, or polysorbate-80 at a concentration of 1 %,.

Conclusions. Octahedin-hexafluorosilicate gels have a wide spectrum of antimicrobial action, which increases with the insertion of essential oils. The use of solubilizers helps to dissolve essential oils and obtain homogeneous gels.

Author Biographies

V. Yu. Anisimov, Odessa National Medical University

candidate of Biological Sciences, associate professor of the Department of Pharmaceutical Chemistry, dean of Pharmaceutical faculty

V. O. Gelmboldt, Odessa National Medical University

Doctor of Chemistry, professor of the Department of Pharmaceutical Chemistry

N. P. Polovko, National University of Pharmacy

Doctor of Pharmaceutical Science, professor, head of the Pharmaceutical Technology of Drugs Department

O. P. Strilets, National University of Pharmacy

Doctor of Pharmaceutical Science, professor of Biotechnology Department


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Biopharmaceutical research