Experimental study of Gluquamine efficacy in the case of tubular kidney damage
DOI:
https://doi.org/10.24959/ubphj.18.170Keywords:
gluquamine, quercetin, glucosamine hydrochloride, N-acetylglucosamine, mercuric chloride nephropathyAbstract
Topicality. Tubular damages take an important place among the causes of chronic kidney disease (CKD). Therefore while searching the effective drugs for CKD treatment it is advisable to study their effect on the tubular apparatus of a pathologically altered kidney.
Aim. Experimental study of Gluquamine efficacy in the case of tubular kidney damage to substantiate the advisability of its using in CKD therapy.
Materials and methods. Mercuric chloride nephropathy in rats was used as a model of tubular renal damage. Diuresis, excretion and clearance of creatinine, tubular reabsorption, urinary activity of lactate dehydrogenase enzymes, γ-glutamyltransferase and N-acetyl-β-D-glucosaminidase were determined in animals.
Results and discussion. 3 weeks after the nephropathy induction under the influence of Gluquamine there was a significant increase relatively to untreated animals of the diuresis, excretion and clearance of creatinine, tubular reabsorption, which indicates the normalization of kidneys functional state. There was also a positive effect on markers content of kidneys tubular apparatus damage, which was manifested in a significant decrease in the level of enzymuria. At the same time by the degree of influence Gluquamine significantly exceeded the activity of comparative drugs quercetin and lesprefil by the majority of parameters.
Conclusions. In the conditions of tubular kidney damage development leading to emergence of renal failure, Gluquamine has a pronounced nephroprotective effect and is a promising drug in CKD therapy.
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