Experimental study of anti-inflammatory properties of exposure “Venosten”
Keywords:anti-inflammatory activity, “Venosten” thick extract, carrageenan edema, zymosan edema
Topicality. The presence of inflammatory process in diseases of veins caused the study of anti-inflammatory activity of the dense extract “Venosten”, which was investigated on models of inflammation with various mechanisms of development: carragenin and zimozanovyh edema.
The aim of this work was to study the anti-inflammatory properties of the new dense “Venosten” extract in the dose range and establish an effective dose for this type of pharmacological activity.
Materials and methods. At the first stage of the study, the study of anti-inflammatory properties on the model of carrageenan edema in rats. It is known that in the pathogenesis of carrageenitis inflammation in 1.5-5.5 hours after the introduction of flogogenic GHG plays a leading role, this allows us to conclude about the effect of the investigated extract on the cyclooxygenase system. In order to establish the ability of the thick extract of “Venosten” to suppress the activity of the key enzymes of the transformation of arachidonic acid in the next stage, we used a model of zymosan edema, whose mechanism of development is the formation of LT (0.5 hours). The anti-inflammatory activity of the thick extract “Venosten” was studied in doses 25 mg/kg, 50 mg/kg and 100 mg/kg.
Results and discussion. The essential extract of “Venosten” in a dose of 100 mg/kg reduced the new caraphaea by a new swelling by 3 hours in 1.8 times (anti-eczual activity 42.2 %). Pre-administration of the “Venosten” Extract of 100 mg/kg significantly impairs the development of zymosan edema. Thus, 0.5 hours after the administration of zymosan to animals, in the rat treated with the “Venosten” extract, the edema was significantly lower than 1.5 times in the control group of pathology. The anti-exudative activity was 32.6 %.
Conclusions. Extract “Venosten” in a dose of 100 mg/kg showed a pronounced anti-exudative activity and the ability to suppress the synthesis of prostaglandins and moderately affect the synthesis of leukotrienes.
1. Mishalov, V. G., Osadii, A. I., Seliuk, V. M. (2002). Hirurhiia Ukrainy, 2, 92-94.
2. Kharkevich, D. A. (2004). Eksperimentalnaia i klinicheskaia farmakologiia, 1, 69–77.
3. Nemchenko, A. S., Kukhtenko, O. S., Gladukh, I. V. (2017). Marketing research of the pharmaceutical market of drugs for treating varicose veins and inflammatory diseases of joints. Socìal’na Farmacìâ v Ohoronì Zdorov’â, 3 (3), 66–73. doi: 10.24959/sphhcj.17.87
4. Kukhtenko, O. S., Hladukh, E. V. (2016). Naukovo-tekhnichnyi prohres i optymizatsiia tekhnolohichnykh protsesiv stvorennia likarskykh preparativ. Ternopil: TDMU, 129-130.
5. Kukhtenko, A. S., Gladuh, E. V. (2015). Aktualnye voprosy obrazovaniia, nauki i proizvodstva v farmatcii. Toshkent, 109-110.
6. Kaminska, O. L., Kuhtenko, O. S. (2014). Tekhnolohichni ta biofarmatsevtychni aspekty stvorennia likarskykh preparativ riznoi napravlenosti dii. Kharkiv, 83.
7. Stefanov, O. V. (2001). Doklіnichni doslidzhennia likarskykh zasobiv. Kyiv: Avitsena, 528.
8. Gado, K., Gigler, G. (1991). Zymozaninflammation. A newmethodsuitablefor: evaluatingnew anti-inflammatorydrugs. AgentsandActions, 32 (1-2), 119 – 121.
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).