Experimental study of cardioprotective properties of viscous extract “Cardiosten”
Keywords:cardioprotective activity, adrenal myocarditis, cardiac mass coefficient, viscous extract “Cardiosten”
Topicality. For treatment of cardiovascular diseases vegetative origin pharmacological preparations with metabolic and cytoprotective effects are increasingly used, but their range is rather limited. Therefore, the search and pharmacological studies of new potent plant origin cardioprotectors are promising.
Aim. To study the effectiveness of the new viscous extract application under the conventional name “Cardiosten” for correction of disorders in the body of rats under heart attack induced by elevated doses of adrenaline.
Materials and methods. The model of catecholamine-induced myocarditis is reproduced by a single injection of 0.18 % adrenaline solution subcutaneously at a rate of 0.5 mg/kg animal body weight. The expressiveness of the alterative processes in the tissue during adrenal lesion of the myocardium was determined by the heart mass coefficient indicator.
Results and discussion. Data analysis has shown that the introduction of a dense extract contributes to an increase in survival of rats with a experimental myocarditis, reduces the degree of heart muscle damage. The cardiosthenic extract at doses of 50 mg/kg and 100 mg/kg, based on the cardioprotective effect of the adrenal myocarditis model, exceeds the effectiveness of the reference drug “Trycardin”.
Conclusions. The conducted research confirmed the cardioprotective properties of the viscous extract “Cardiosten”, which makes this pharmacological preparation promising for its further study in order to introduce into the production and application in the clinic of cardiovascular diseases.
Gromovaia, V. F., Shapoval, G. S., Mironiuk I. E., Nestiuk, N. V. (2008). Khimiko-farmatcevticheskii zhurnal, 42, (3), 26–29.
Hulaha, O. I., Tashchuk, V. K., Polianska, O. S. (2010). Bukovynskyi medychnyi visnyk, 14 (2 (54)), 122–124.
Kukhtenko, O. S., Symonian, L. S., Hladukh, Ye. V. (2017), Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky, 10 (2), 219–223.
Kukhtenko, O. S., Hladukh, Ye. V., Nazarkyna, V. N. (2017). Retsept, 20 (4), 516–523.
Kukhtenko, O. S., Hladukh, E. V. (2014). Farmakoekonomika v Ukraini: Stan ta perspektyvy rozvytku. Materialy VII naukovo-praktychnoi Internet –
konferentsii. (20.11.2014). (pp. 133–134). Kharkiv.
Nepomniashchikh, L. M. (1998). Alternativnaia nedostatochnost myshechnykh kletok serdtca pri metabolicheskikh i ishemicheskikh povrezhdeniiakh.
Chuvaev, I. V., Glotova, S. V. (2009). Materialy Vserossiiskogo sezda veterinarnikh farmakologov i toksikologov «Effektivnye i bezopasnye lekarstvennye sredstva v veterinarii». Sankt-Peterburg, 28–31.
Stephanov, A. V. (2002). Doklinicheskie issledovaniia lekarstvennyh sredstv. Kiev: Avitcenna, 528.
Shchokina, K. H., Shtryhol, S. Yu., Bielik, H. V., Butko, Ya. O. (2010). Ukraïns’kij bìofarmacevtičnij žurnal, 2 (7), 39–45.
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).