DOI: https://doi.org/10.24959/ubphj.18.188

Pharmacological effect of a new gel, which contains oak bark extract and aloe extract under the condition of experimental stomatitis in rats

N. Tsubanova, D. S. Zhurenko

Abstract


Topicality. Aloe extract and oak bark extract are considered to be the most perspective medicinal raw materials in new drug development for dental practice.

Aim. Aloe extract and oak bark extract are promising medicines for the development of a new drug for dental practice.

Materials and methods. Experimental stomatitis was reconstituted by a one-time 5-second application with a cotton swab filled with a 10 % solution of sodium hydroxide. In the blood were investigated content of leukocytes and rate of erythrocyte sedimentation rate (ESR). The activity of catalase measured in tongue homogenate, and determined the content of reduced glutathione and thiobarbituric acid reagents. Metrogyl Denta was used as a comparison drug.

Results and discussion. It was established that the new gel is likely to exceed the Metrogyl Denta for a decrease in the clinical parameters of stomatitis (hyperemia, edema, erosive-necrotic changes). The gel which contains oak bark extract and aloe extract have anti-inflammatory effect, reduces leukocytosis and ESR. The new gel have significant advantages over Metrogyl Denta, by high antioxidant effect, which is determined by the activity of catalase and indicators of reduced glutathione and thiobarbituric acid reagents.

Conclusions. The new gel, which contains oak bark extract and aloe extract, is found to be an effective remedy for the treatment of experimental stomatitis, can be considered promising for further research and implementation into medical practice.


Keywords


gel; oak bark extract; aloe extract; stomatitis

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References


Hebert, C. G., DiNardo, N., Evans, Z. L., Hart, S. J., & Hachmann, A.-B. (2018). Rapid quantification of vesicular stomatitis virus in Vero cells using Laser Force Cytology. Vaccine, 36 (41), 6061–6069. https://doi.org/10.1016/j.vaccine.2018.09.002

Miller A. L., Long I. M., Hrystyan G. E. (2015) Integral characteristics of infectious and inflammatory diseases of the mouth. Clinical and Experimental patolohiya, 14 (1 (51)), 215–220.

Kansky, A. A., Didanovic, V., Dovsak, T., Brzak, B. L., Pelivan, I., & Terlevic, D. (2018). Epidemiology of oral mucosal lesions in Slovenia. Radiology and Oncology, 52 (3), 263–266. https://doi.org/10.2478/raon-2018-0031

Kato, S., Saito, A., Matsuda, N., Suzuki, H., Ujiie, M., Sato, S., … Satoh, H. (2017). Management of afatinib-induced stomatitis. Molecular and Clinical Oncology, 6 (4), 603–605. https://doi.org/10.3892/mco.2017.1184

Sonis, S., Andreotta, P., & Lyng, G. (2017). On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa. Oral Diseases, 23 (3), 347–352. https://doi.org/10.1111/odi.12616

Zhang, Z., Li, S., & Fang, H. (2017). Enzymatic antioxidants status in patients with recurrent aphthous stomatitis. Journal of Oral Pathology & Medicine, 46 (9), 817–820. https://doi.org/10.1111/jop.12547

Nasry, S., El Shenawy, H., Mostafa, D., & Ammar, N. (2016). Different modalities for treatment of recurrent aphthous stomatitis. A Randomized clinical trial. Journal of Clinical and Experimental Dentistry, 5, 517–522. https://doi.org/10.4317/jced.52877

Sahebjamee M., Mansourian A., Hajimirzamohammad M., Zadeh, M. T., Bekhradi, R., … Doroudgar, K. (2015) Comparative efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-Induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial. Oral Health Prev Dent., 4, 309–315. https://doi.org/10.3290/j.ohpd.a33091

Mansouri P., Haghighi M., Beheshtipour N., Ramzi, M. (2016) The effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial. Int J Community Based Nurs Midwifery, 4 (2), 119–126.

Stefaniv, I. V., Yakovlieva, L. V., Hrashchenkova, S. A. (2014). Klinichna farmatsiia, farmakoterapiia ta medychna standartyzatsiia, 1-2, 23–29.

StatPlus. (n.d.). AnalystSoft Inc. Available at: www.analystsoft.com/ru

Zhurenko, D. S., Tsubanova, N. A., Khokhlenkova, N. V., Artiukh, T. O. (2017). Screening Study for Finding the Optimal Combination Gel Composition for the Treatment of Periodontal Disease, Which Contains Extracts Of Aloe Vera And Oak Bark. Asian Journal of Pharmaceutics, 11(2), 353–357.


GOST Style Citations


1. Rapid quantification of vesicular stomatitis virus in Vero cells using Laser Force Cytology / C. G. Hebert, N. DiNardo, Z. L. Evans [et al.] // Vaccine. – 2018. – Vol. 36 (41). – P. 6061–6069. https://doi.org/10.1016/j.vaccine.2018.09.002

2. Miller, A. L. Integral characteristics of infectious and inflammatory diseases of the mouth / A. L. Miller, I. M. Long, G. E. Hrystyan // Clinical and Experimental Patolohiya. – 2015. – T. XIV, № 1 (51). – P. 215–220.

3. Epidemiology of oral mucosal lesions in Slovenia / A. A. Kansky, V. Didanovic, T. Dovsak [et al.] // Radiol. Oncol. – 2018. – № 52. – P. 263–266. https://doi.org/10.2478/raon-2018-0031

4. Management of afatinib-induced stomatitis / S. Kato, A. Saito, N. Matsuda [et al.] // Mol. Clin. Oncol. – 2017. – № 4. – P. 603–605. https://doi.org/10.3892/mco.2017.1184

5. Sonis, S. On the pathogenesis of mTOR inhibitor-associated stomatitis (mIAS)-studies using an organotypic model of the oral mucosa / S. Sonis, P. W. Andreotta, G. Lyng // Oral Dis. – 2017. – № 3. – P. 347–352. https://doi.org/10.1111/odi.12616

6. Zhang, Z. Enzymatic antioxidants in patients with recurrent aphthous stomatitis / Z. Zhang, S. Li, H. Fang // J. Oral Pathol. Med. – 2017. – № 46 (9). – P. 817–820. https://doi.org/10.1111/jop.12547

7. Different modalities for the treatment of recurrent aphthous stomatitis. A Randomized clinical trial / S. A. Nasry, H. M. El Shenawy, D. Mostafa [et al.] // J. Clin. Exp. Dent. – 2016. – № 5. – P. 517–522. https://doi.org/10.4317/jced.52877

8. Comparative efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-Induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial / M. Sahebjamee, A. Mansourian, M. Hajimirzamohammad [et al.] // Oral Health Prev. Dent. – 2015. – № 4. – P. 309–315. https://doi.org/10.3290/j.ohpd.a33091

9. The effect of Aloe Vera Solution on Chemotherapy-Induced Stomatitis in Clients with Lymphoma and Leukemia: A Randomized Controlled Clinical Trial / P. Mansouri, M. Haghighi, N. Beheshtipour [et al.] // Int. J. Community Based Nurs Midwifery. – 2016. – № 2. – P. 119–126.

10. Стефанів, І. В. Дослідження лікувальної дії стоматологічної настойки «Касдент» на моделі стоматиту у щурів / І. В. Стефанів, Л. В. Яковлєва, С. А. Гращенкова // Клін. фармація, фармакотерапія та мед. стандартизація. – 2014. – № 1–2. – С. 23–29.

11. StatPlus // AnalystSoft Inc. – Режим доступу : www.analystsoft.com/ru

12. Screening Study for Finding the Optimal Combination Gel Composition for the Treatment of Periodontal Disease., Which Contains Extracts of Aloe Vera and Oak Bark / N. A. Tsubanova, D. S. Zhurenko, N. V. Khokhlenkova, T. O. Artiukh // Asian J. of Pharmaceutics. – 2017. – Vol. 11 (2). – P. 353–357.




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